COVID-19 and alcohol use disorder: putative differential gene expression patterns that might be associated with neurological complications

Jibran Sualeh Muhammad; Ruqaiyyah Siddiqui; Naveed Ahmed Khan

doi:10.1080/21548331.2022.2088183

COVID-19 and alcohol use disorder: putative differential gene expression patterns that might be associated with neurological complications

Jibran Sualeh Muhammad^*
, Ruqaiyyah Siddiqui
, Naveed Ahmed Khan^*

^*Corresponding author for this work

Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Several lines of evidence suggest that SARS-CoV-2 invasion of the central nervous system leads to meningitis and encephalopathy syndromes. Additionally, chronic alcoholics were found to be at a higher risk of developing mental health problems and serious neurological manifestations, if exposed to SARS-CoV-2 infection.

Methods: Herein, we studied RNA seq data from alcoholics’ brain tissue and COVID-19 patient’s brain tissue to identify the common differentially expressed genes.

Results: Overlap analysis depicted the expression of seven genes (GHRL, SLN, VGF, IL1RL1, NPTX2, PDYN, and RPRML) that were significantly upregulated in both groups. Along with these, protein–protein interaction analysis revealed 10 other key molecules with strong interactions with the aforementioned genes.

Conclusions: Taken together with the functional effect of these genes, we suggest a strong molecular link between COVID-19-induced severities and neurological impairment in patients suffering from alcohol abuse disorder. These findings emphasize the importance of identifying chronic alcoholism as a risk factor for developing cognitive and memory impairment in COVID-19 patients.

Original language	English
Pages (from-to)	189-195
Number of pages	7
Journal	Hospital Practice
Volume	50
Issue number	3
DOIs	https://doi.org/10.1080/21548331.2022.2088183
Publication status	Published - 20 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcoholism
COVID-19
in silico analysis
neurological manifestations
SARS-CoV-2

ASJC Scopus subject areas

Clinical Biochemistry
Health Information Management
General Medicine

Access to Document

10.1080/21548331.2022.2088183

Cite this

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title = "COVID-19 and alcohol use disorder: putative differential gene expression patterns that might be associated with neurological complications",

abstract = "Background: Several lines of evidence suggest that SARS-CoV-2 invasion of the central nervous system leads to meningitis and encephalopathy syndromes. Additionally, chronic alcoholics were found to be at a higher risk of developing mental health problems and serious neurological manifestations, if exposed to SARS-CoV-2 infection. Methods: Herein, we studied RNA seq data from alcoholics{\textquoteright} brain tissue and COVID-19 patient{\textquoteright}s brain tissue to identify the common differentially expressed genes. Results: Overlap analysis depicted the expression of seven genes (GHRL, SLN, VGF, IL1RL1, NPTX2, PDYN, and RPRML) that were significantly upregulated in both groups. Along with these, protein–protein interaction analysis revealed 10 other key molecules with strong interactions with the aforementioned genes. Conclusions: Taken together with the functional effect of these genes, we suggest a strong molecular link between COVID-19-induced severities and neurological impairment in patients suffering from alcohol abuse disorder. These findings emphasize the importance of identifying chronic alcoholism as a risk factor for developing cognitive and memory impairment in COVID-19 patients.",

keywords = "Alcoholism, COVID-19, in silico analysis, neurological manifestations, SARS-CoV-2",

author = "Muhammad, \{Jibran Sualeh\} and Ruqaiyyah Siddiqui and Khan, \{Naveed Ahmed\}",

note = "Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2022",

month = jun,

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doi = "10.1080/21548331.2022.2088183",

language = "English",

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T2 - putative differential gene expression patterns that might be associated with neurological complications

AU - Muhammad, Jibran Sualeh

AU - Siddiqui, Ruqaiyyah

AU - Khan, Naveed Ahmed

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Background: Several lines of evidence suggest that SARS-CoV-2 invasion of the central nervous system leads to meningitis and encephalopathy syndromes. Additionally, chronic alcoholics were found to be at a higher risk of developing mental health problems and serious neurological manifestations, if exposed to SARS-CoV-2 infection. Methods: Herein, we studied RNA seq data from alcoholics’ brain tissue and COVID-19 patient’s brain tissue to identify the common differentially expressed genes. Results: Overlap analysis depicted the expression of seven genes (GHRL, SLN, VGF, IL1RL1, NPTX2, PDYN, and RPRML) that were significantly upregulated in both groups. Along with these, protein–protein interaction analysis revealed 10 other key molecules with strong interactions with the aforementioned genes. Conclusions: Taken together with the functional effect of these genes, we suggest a strong molecular link between COVID-19-induced severities and neurological impairment in patients suffering from alcohol abuse disorder. These findings emphasize the importance of identifying chronic alcoholism as a risk factor for developing cognitive and memory impairment in COVID-19 patients.

AB - Background: Several lines of evidence suggest that SARS-CoV-2 invasion of the central nervous system leads to meningitis and encephalopathy syndromes. Additionally, chronic alcoholics were found to be at a higher risk of developing mental health problems and serious neurological manifestations, if exposed to SARS-CoV-2 infection. Methods: Herein, we studied RNA seq data from alcoholics’ brain tissue and COVID-19 patient’s brain tissue to identify the common differentially expressed genes. Results: Overlap analysis depicted the expression of seven genes (GHRL, SLN, VGF, IL1RL1, NPTX2, PDYN, and RPRML) that were significantly upregulated in both groups. Along with these, protein–protein interaction analysis revealed 10 other key molecules with strong interactions with the aforementioned genes. Conclusions: Taken together with the functional effect of these genes, we suggest a strong molecular link between COVID-19-induced severities and neurological impairment in patients suffering from alcohol abuse disorder. These findings emphasize the importance of identifying chronic alcoholism as a risk factor for developing cognitive and memory impairment in COVID-19 patients.

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KW - COVID-19

KW - in silico analysis

KW - neurological manifestations

KW - SARS-CoV-2

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VL - 50

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ER -

COVID-19 and alcohol use disorder: putative differential gene expression patterns that might be associated with neurological complications

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this