Cortical reorganization in an astronaut’s brain after long-duration spaceflight

Athena Demertzi; Angelique Van Ombergen; Elena Tomilovskaya; Ben Jeurissen; Ekaterina Pechenkova; Carol Di Perri; Liudmila Litvinova; Enrico Amico; Alena Rumshiskaya; Ilya Rukavishnikov; Jan Sijbers; Valentin Sinitsyn; Inessa B. Kozlovskaya; Stefan Sunaert; Paul M. Parizel; Paul H. Van de Heyning; Steven Laureys; Floris L. Wuyts

doi:10.1007/s00429-015-1054-3

Cortical reorganization in an astronaut’s brain after long-duration spaceflight

Athena Demertzi, Angelique Van Ombergen^*, Elena Tomilovskaya, Ben Jeurissen, Ekaterina Pechenkova, Carol Di Perri, Liudmila Litvinova, Enrico Amico, Alena Rumshiskaya, Ilya Rukavishnikov, Jan Sijbers, Valentin Sinitsyn, Inessa B. Kozlovskaya, Stefan Sunaert, Paul M. Parizel, Paul H. Van de Heyning, Steven Laureys, Floris L. Wuyts

^*Corresponding author for this work

Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

Original language	English
Pages (from-to)	2873-2876
Number of pages	4
Journal	Brain Structure and Function
Volume	221
Issue number	5
Early online date	12 May 2015
DOIs	https://doi.org/10.1007/s00429-015-1054-3
Publication status	Published - Jun 2016

Bibliographical note

Copyright:
© 2016, The Author(s).

Keywords

Cortical reorganization
Functional MRI
Microgravity
Motor behavior
Vestibular cortex

ASJC Scopus subject areas

Anatomy
General Neuroscience
Histology

Access to Document

10.1007/s00429-015-1054-3Licence: Creative Commons: Attribution (CC BY)

Cite this

Demertzi, A., Van Ombergen, A., Tomilovskaya, E., Jeurissen, B., Pechenkova, E., Di Perri, C., Litvinova, L., Amico, E., Rumshiskaya, A., Rukavishnikov, I., Sijbers, J., Sinitsyn, V., Kozlovskaya, I. B., Sunaert, S., Parizel, P. M., Van de Heyning, P. H., Laureys, S., & Wuyts, F. L. (2016). Cortical reorganization in an astronaut’s brain after long-duration spaceflight. Brain Structure and Function, 221(5), 2873-2876. https://doi.org/10.1007/s00429-015-1054-3

@article{1536c72aa84d4b11856963af34cf3971,

title = "Cortical reorganization in an astronaut{\textquoteright}s brain after long-duration spaceflight",

abstract = "To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.",

keywords = "Cortical reorganization, Functional MRI, Microgravity, Motor behavior, Vestibular cortex",

author = "Athena Demertzi and {Van Ombergen}, Angelique and Elena Tomilovskaya and Ben Jeurissen and Ekaterina Pechenkova and {Di Perri}, Carol and Liudmila Litvinova and Enrico Amico and Alena Rumshiskaya and Ilya Rukavishnikov and Jan Sijbers and Valentin Sinitsyn and Kozlovskaya, {Inessa B.} and Stefan Sunaert and Parizel, {Paul M.} and {Van de Heyning}, {Paul H.} and Steven Laureys and Wuyts, {Floris L.}",

note = "Copyright: {\textcopyright} 2016, The Author(s).",

year = "2016",

month = jun,

doi = "10.1007/s00429-015-1054-3",

language = "English",

volume = "221",

pages = "2873--2876",

journal = "Brain Structure and Function",

issn = "1863-2653",

publisher = "Springer",

number = "5",

}

Demertzi, A, Van Ombergen, A, Tomilovskaya, E, Jeurissen, B, Pechenkova, E, Di Perri, C, Litvinova, L, Amico, E, Rumshiskaya, A, Rukavishnikov, I, Sijbers, J, Sinitsyn, V, Kozlovskaya, IB, Sunaert, S, Parizel, PM, Van de Heyning, PH, Laureys, S & Wuyts, FL 2016, 'Cortical reorganization in an astronaut’s brain after long-duration spaceflight', Brain Structure and Function, vol. 221, no. 5, pp. 2873-2876. https://doi.org/10.1007/s00429-015-1054-3

TY - JOUR

T1 - Cortical reorganization in an astronaut’s brain after long-duration spaceflight

AU - Demertzi, Athena

AU - Van Ombergen, Angelique

AU - Tomilovskaya, Elena

AU - Jeurissen, Ben

AU - Pechenkova, Ekaterina

AU - Di Perri, Carol

AU - Litvinova, Liudmila

AU - Amico, Enrico

AU - Rumshiskaya, Alena

AU - Rukavishnikov, Ilya

AU - Sijbers, Jan

AU - Sinitsyn, Valentin

AU - Kozlovskaya, Inessa B.

AU - Sunaert, Stefan

AU - Parizel, Paul M.

AU - Van de Heyning, Paul H.

AU - Laureys, Steven

AU - Wuyts, Floris L.

PY - 2016/6

Y1 - 2016/6

N2 - To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

AB - To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

KW - Cortical reorganization

KW - Functional MRI

KW - Microgravity

KW - Motor behavior

KW - Vestibular cortex

UR - http://www.scopus.com/inward/record.url?scp=84929180161&partnerID=8YFLogxK

U2 - 10.1007/s00429-015-1054-3

DO - 10.1007/s00429-015-1054-3

M3 - Article

C2 - 25963710

AN - SCOPUS:84929180161

SN - 1863-2653

VL - 221

SP - 2873

EP - 2876

JO - Brain Structure and Function

JF - Brain Structure and Function

IS - 5

ER -

Cortical reorganization in an astronaut’s brain after long-duration spaceflight

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this