Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system

S Javerzat; M Franco; John Herbert; N Platonova; AL Peille; V Pantesco; J De Vos; S Assou; Roy Bicknell; A Bikfalvi; M Hagedorn

doi:10.1371/journal.pone.0007856

Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system

S Javerzat, M Franco, John Herbert, N Platonova, AL Peille, V Pantesco, J De Vos, S Assou, Roy Bicknell, A Bikfalvi, M Hagedorn

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Abstract

BACKGROUND: Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis. METHOLOGY/PRINCIPAL FINDINGS: We accessed global gene regulation throughout maturation of the chick chorio-allantoic membrane (CAM), a highly vascularized tissue, using pan genomic microarrays. Seven percent of analyzed genes showed a significant change in expression (>2-fold, FDR

Original language	English
Pages (from-to)	e7856
Journal	PLoS ONE
Volume	4
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0007856
Publication status	Published - 1 Jan 2009

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AU - Javerzat, S

AU - Franco, M

AU - Herbert, John

AU - Platonova, N

AU - Peille, AL

AU - Pantesco, V

AU - De Vos, J

AU - Assou, S

AU - Bicknell, Roy

AU - Bikfalvi, A

AU - Hagedorn, M

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AB - BACKGROUND: Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis. METHOLOGY/PRINCIPAL FINDINGS: We accessed global gene regulation throughout maturation of the chick chorio-allantoic membrane (CAM), a highly vascularized tissue, using pan genomic microarrays. Seven percent of analyzed genes showed a significant change in expression (>2-fold, FDR

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Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system

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