Corpus callosum abnormalities in Tourette syndrome: a MRI-DTI study of monozygotic twins

Andrea Cavanna, A Stecco, Hugh Rickards, S Servo, E Terazzi, B Peterson, MM Robertson, A Carriero, F Monaco

Research output: Contribution to journalArticle

29 Citations (Scopus)


BACKGROUND: Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes. METHODS: We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS. RESULTS: Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p
Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number5
Publication statusPublished - 1 Jan 2009


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