Control of nuclear receptor function by local chromatin structure

Malgorzata Wiench, TB Miranda, GL Hager

Research output: Contribution to journalArticle

28 Citations (Scopus)


Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling complexes, as well as histone and DNA modifying enzymes, are directed to gene-specific regions and create permissive or repressive chromatin environments. These structures further enable proper communication between transcription factors, co-regulators and basic transcription machinery. The regulatory elements active at target genes can be either constitutively accessible to receptors or subject to rapid receptor-dependent modification. The chromatin states responsible for these processes are in turn determined during development and differentiation. Thus access of regulatory factors to elements in chromatin provides a major level of cell selective regulation.
Original languageEnglish
Pages (from-to)2211-2230
Number of pages20
JournalFEBS Journal
Issue number13
Publication statusPublished - 1 Jul 2011


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