Control of gene expression in Plasmodium falciparum - Ten years on

Paul Horrocks; Eleanor Wong; Karen Russell; Richard D. Emes

doi:10.1016/j.molbiopara.2008.11.010

Control of gene expression in Plasmodium falciparum - Ten years on

Paul Horrocks^*
, Eleanor Wong
, Karen Russell
, Richard D. Emes

^*Corresponding author for this work

Biosciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Ten years ago this journal published a review with an almost identical title detailing how the then recent introduction of transfection technology had advanced our understanding of the molecular control of transcriptional processes in Plasmodium falciparum, particularly in terms of promoter structure and function. In the succeeding years, sequencing of several Plasmodium spp. genomes and application of high throughput global postgenomic technologies have proven as significant, if not more, as has the ability to genetically manipulate these parasites in dissecting the molecular control of gene expression. Here we aim to review our current understanding of the control of gene expression in P. falciparum, including evidence available from other Plasmodium spp. and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years. Crown

Original language	English
Pages (from-to)	9-25
Number of pages	17
Journal	Molecular and biochemical parasitology
Volume	164
Issue number	1
DOIs	https://doi.org/10.1016/j.molbiopara.2008.11.010
Publication status	Published - Mar 2009

Bibliographical note

Funding Information:
We would like to thank our colleagues and anonymous reviewers who provided valuable discussion as well as critical reading of this manuscript, particularly acknowledging the contribution of Sue Kyes. We also wish to acknowledge support from the Keele University Medical School (P.H., E.W., R.D.E.), the Biotechnology and Biological Sciences Research Council (K.R.) and The Royal Society (P.H.).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antisense transcripts
Bioinformatics
Chromatin
Epigenetics
Malaria
mRNA stability
ncRNA
Promoter
Transcription
Transcription factors

ASJC Scopus subject areas

Parasitology
Molecular Biology

Access to Document

10.1016/j.molbiopara.2008.11.010

Cite this

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title = "Control of gene expression in Plasmodium falciparum - Ten years on",

abstract = "Ten years ago this journal published a review with an almost identical title detailing how the then recent introduction of transfection technology had advanced our understanding of the molecular control of transcriptional processes in Plasmodium falciparum, particularly in terms of promoter structure and function. In the succeeding years, sequencing of several Plasmodium spp. genomes and application of high throughput global postgenomic technologies have proven as significant, if not more, as has the ability to genetically manipulate these parasites in dissecting the molecular control of gene expression. Here we aim to review our current understanding of the control of gene expression in P. falciparum, including evidence available from other Plasmodium spp. and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years. Crown",

keywords = "Antisense transcripts, Bioinformatics, Chromatin, Epigenetics, Malaria, mRNA stability, ncRNA, Promoter, Transcription, Transcription factors",

author = "Paul Horrocks and Eleanor Wong and Karen Russell and Emes, \{Richard D.\}",

note = "Funding Information: We would like to thank our colleagues and anonymous reviewers who provided valuable discussion as well as critical reading of this manuscript, particularly acknowledging the contribution of Sue Kyes. We also wish to acknowledge support from the Keele University Medical School (P.H., E.W., R.D.E.), the Biotechnology and Biological Sciences Research Council (K.R.) and The Royal Society (P.H.).",

year = "2009",

month = mar,

doi = "10.1016/j.molbiopara.2008.11.010",

language = "English",

volume = "164",

pages = "9--25",

journal = "Molecular and biochemical parasitology",

issn = "0166-6851",

publisher = "Elsevier",

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T1 - Control of gene expression in Plasmodium falciparum - Ten years on

AU - Horrocks, Paul

AU - Wong, Eleanor

AU - Russell, Karen

AU - Emes, Richard D.

N1 - Funding Information: We would like to thank our colleagues and anonymous reviewers who provided valuable discussion as well as critical reading of this manuscript, particularly acknowledging the contribution of Sue Kyes. We also wish to acknowledge support from the Keele University Medical School (P.H., E.W., R.D.E.), the Biotechnology and Biological Sciences Research Council (K.R.) and The Royal Society (P.H.).

PY - 2009/3

Y1 - 2009/3

N2 - Ten years ago this journal published a review with an almost identical title detailing how the then recent introduction of transfection technology had advanced our understanding of the molecular control of transcriptional processes in Plasmodium falciparum, particularly in terms of promoter structure and function. In the succeeding years, sequencing of several Plasmodium spp. genomes and application of high throughput global postgenomic technologies have proven as significant, if not more, as has the ability to genetically manipulate these parasites in dissecting the molecular control of gene expression. Here we aim to review our current understanding of the control of gene expression in P. falciparum, including evidence available from other Plasmodium spp. and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years. Crown

AB - Ten years ago this journal published a review with an almost identical title detailing how the then recent introduction of transfection technology had advanced our understanding of the molecular control of transcriptional processes in Plasmodium falciparum, particularly in terms of promoter structure and function. In the succeeding years, sequencing of several Plasmodium spp. genomes and application of high throughput global postgenomic technologies have proven as significant, if not more, as has the ability to genetically manipulate these parasites in dissecting the molecular control of gene expression. Here we aim to review our current understanding of the control of gene expression in P. falciparum, including evidence available from other Plasmodium spp. and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years. Crown

KW - Antisense transcripts

KW - Bioinformatics

KW - Chromatin

KW - Epigenetics

KW - Malaria

KW - mRNA stability

KW - ncRNA

KW - Promoter

KW - Transcription

KW - Transcription factors

UR - https://www.scopus.com/pages/publications/58549094894

U2 - 10.1016/j.molbiopara.2008.11.010

DO - 10.1016/j.molbiopara.2008.11.010

M3 - Review article

C2 - 19110008

AN - SCOPUS:58549094894

SN - 0166-6851

VL - 164

SP - 9

EP - 25

JO - Molecular and biochemical parasitology

JF - Molecular and biochemical parasitology

IS - 1

ER -

Control of gene expression in Plasmodium falciparum - Ten years on

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this