The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.
|Title of host publication
|Epstein Barr Virus Volume 1
|Subtitle of host publication
|One Herpes Virus: Many Diseases
|Number of pages
|Published - 1 Oct 2015
|Current Topics in Microbiology and Immunology