The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.
|Title of host publication||Epstein Barr Virus Volume 1|
|Subtitle of host publication||One Herpes Virus: Many Diseases|
|Number of pages||27|
|Publication status||Published - 1 Oct 2015|
|Name||Current Topics in Microbiology and Immunology|