Conjugated Linoleic Acid Impairs Endothelial Function

JS Taylor, SR Williams, R Rhys, P James, Michael Frenneaux

Research output: Contribution to journalArticle

80 Citations (Scopus)


OBJECTIVE: To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk. METHODS AND RESULTS: Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P
Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalArteriosclerosis Thrombosis and Vascular Biology
Issue number2
Early online date1 Dec 2005
Publication statusPublished - 1 Dec 2005


  • endothelial function
  • body composition
  • obesity
  • conjugated linoleic acid
  • oxidative stress


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