Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

Renata I. Zagitova; Konstantin V. Purtov; Aleksandr S. Shcheglov; Konstantin S. Mineev; Maxim A. Dubinnyi; Ivan N. Myasnyanko; Olga A. Belozerova; Vera G. Pakhomova; Valentin N. Petushkov; Natalia S. Rodionova; Vladislav A. Lushpa; Elena B. Guglya; Sergey Kovalchuk; Valeri B. Kozhemyako; Jeremy D. Mirza; Anderson G. Oliveira; Ilia V. Yampolsky; Zinaida M. Kaskova; Aleksandra S. Tsarkova

doi:10.3390/ijms24119466

Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

Renata I. Zagitova, Konstantin V. Purtov, Aleksandr S. Shcheglov, Konstantin S. Mineev, Maxim A. Dubinnyi, Ivan N. Myasnyanko, Olga A. Belozerova, Vera G. Pakhomova, Valentin N. Petushkov, Natalia S. Rodionova, Vladislav A. Lushpa, Elena B. Guglya, Sergey Kovalchuk, Valeri B. Kozhemyako, Jeremy D. Mirza, Anderson G. Oliveira, Ilia V. Yampolsky, Zinaida M. Kaskova, Aleksandra S. Tsarkova^*

^*Corresponding author for this work

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Abstract

Biochemistry of bioluminescence of the marine parchment tubeworm Chaetopterus has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from Chaetomorpha linum algae, which demonstrate bioluminescence activity with Chaetopterus luciferase in the presence of Fe²⁺ ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.

Original language	English
Article number	9466
Number of pages	12
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	11
DOIs	https://doi.org/10.3390/ijms24119466
Publication status	Published - 30 May 2023

Keywords

luciferin
ferroptosis
bioluminescence
parchment worm
luciferase
Chaetopterus
bioimaging
biomedical research
lipid peroxidation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zagitova, R. I., Purtov, K. V., Shcheglov, A. S., Mineev, K. S., Dubinnyi, M. A., Myasnyanko, I. N., Belozerova, O. A., Pakhomova, V. G., Petushkov, V. N., Rodionova, N. S., Lushpa, V. A., Guglya, E. B., Kovalchuk, S., Kozhemyako, V. B., Mirza, J. D., Oliveira, A. G., Yampolsky, I. V., Kaskova, Z. M., & Tsarkova, A. S. (2023). Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System. International Journal of Molecular Sciences, 24(11), Article 9466. https://doi.org/10.3390/ijms24119466

@article{8f70cb44ec4e43e985edd60882058542,

title = "Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System",

abstract = "Biochemistry of bioluminescence of the marine parchment tubeworm Chaetopterus has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from Chaetomorpha linum algae, which demonstrate bioluminescence activity with Chaetopterus luciferase in the presence of Fe2+ ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.",

keywords = "luciferin, ferroptosis, bioluminescence, parchment worm, luciferase, Chaetopterus, bioimaging, biomedical research, lipid peroxidation",

author = "Zagitova, {Renata I.} and Purtov, {Konstantin V.} and Shcheglov, {Aleksandr S.} and Mineev, {Konstantin S.} and Dubinnyi, {Maxim A.} and Myasnyanko, {Ivan N.} and Belozerova, {Olga A.} and Pakhomova, {Vera G.} and Petushkov, {Valentin N.} and Rodionova, {Natalia S.} and Lushpa, {Vladislav A.} and Guglya, {Elena B.} and Sergey Kovalchuk and Kozhemyako, {Valeri B.} and Mirza, {Jeremy D.} and Oliveira, {Anderson G.} and Yampolsky, {Ilia V.} and Kaskova, {Zinaida M.} and Tsarkova, {Aleksandra S.}",

year = "2023",

month = may,

day = "30",

doi = "10.3390/ijms24119466",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "MDPI",

number = "11",

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Zagitova, RI, Purtov, KV, Shcheglov, AS, Mineev, KS, Dubinnyi, MA, Myasnyanko, IN, Belozerova, OA, Pakhomova, VG, Petushkov, VN, Rodionova, NS, Lushpa, VA, Guglya, EB, Kovalchuk, S, Kozhemyako, VB, Mirza, JD, Oliveira, AG, Yampolsky, IV, Kaskova, ZM & Tsarkova, AS 2023, 'Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System', International Journal of Molecular Sciences, vol. 24, no. 11, 9466. https://doi.org/10.3390/ijms24119466

TY - JOUR

T1 - Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

AU - Zagitova, Renata I.

AU - Purtov, Konstantin V.

AU - Shcheglov, Aleksandr S.

AU - Mineev, Konstantin S.

AU - Dubinnyi, Maxim A.

AU - Myasnyanko, Ivan N.

AU - Belozerova, Olga A.

AU - Pakhomova, Vera G.

AU - Petushkov, Valentin N.

AU - Rodionova, Natalia S.

AU - Lushpa, Vladislav A.

AU - Guglya, Elena B.

AU - Kovalchuk, Sergey

AU - Kozhemyako, Valeri B.

AU - Mirza, Jeremy D.

AU - Oliveira, Anderson G.

AU - Yampolsky, Ilia V.

AU - Kaskova, Zinaida M.

AU - Tsarkova, Aleksandra S.

PY - 2023/5/30

Y1 - 2023/5/30

N2 - Biochemistry of bioluminescence of the marine parchment tubeworm Chaetopterus has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from Chaetomorpha linum algae, which demonstrate bioluminescence activity with Chaetopterus luciferase in the presence of Fe2+ ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.

AB - Biochemistry of bioluminescence of the marine parchment tubeworm Chaetopterus has been in research focus for over a century; however, the results obtained by various groups contradict each other. Here, we report the isolation and structural elucidation of three compounds from Chaetomorpha linum algae, which demonstrate bioluminescence activity with Chaetopterus luciferase in the presence of Fe2+ ions. These compounds are derivatives of polyunsaturated fatty acid peroxides. We have also obtained their structural analogues and demonstrated their activity in the bioluminescence reaction, thus confirming the broad substrate specificity of the luciferase.

KW - luciferin

KW - ferroptosis

KW - bioluminescence

KW - parchment worm

KW - luciferase

KW - Chaetopterus

KW - bioimaging

KW - biomedical research

KW - lipid peroxidation

U2 - 10.3390/ijms24119466

DO - 10.3390/ijms24119466

M3 - Article

SN - 1661-6596

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 11

M1 - 9466

ER -

Conjugated Dienoic Acid Peroxides as Substrates in Chaetopterus Bioluminescence System

Abstract

Keywords

UN SDGs

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