Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

Mary-beth Wandel, Craig A Bell, Jiayi Yu, Maria Chiara Arno, Nathan Dreger, Yen-Hao Hsu, Anaïs Pitto-barry, Josh Worch, Andrew Dove, Matthew L Becker

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
67 Downloads (Pure)

Abstract

Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
Original languageEnglish
Article number446
Number of pages13
JournalNature Communications
Volume12
Issue number1
Early online date19 Jan 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • degradation properties
  • cis:trans
  • resorption
  • concomitant control
  • stoichiometry

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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