Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
Bibliographical noteFunding Information:
We are grateful for financial support from the Biomaterials Division of the National Science Foundation (DMR-1507420), the W. Gerald Austen Endowed Chair in Polymer Science and Polymer Engineering via the John S. and James L. Knight Foundation (MLB), ERC Grant (Number 681559) (APD), and the National Health and Medical Research Council (NHMRC) of Australia (APP 1054569) (CAB). The authors would like to thank Gina M. Policastro for monomer synthesis, James A. Wilson for polymer precursor synthesis, Derek Luong for help with in vitro assessments, Dr. Christopher Klonk and Dr. Christopher Premanandan for assistance with histological assessments.
© 2021, The Author(s).
- degradation properties
- concomitant control
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Biochemistry, Genetics and Molecular Biology(all)