Computational study of ATP gated Potassium ion channel in urinary bladder over activity

Chitaranjan Mahapatra; Keith Brain; Rohit Manchanda

doi:10.1109/INVENTIVE.2016.7824861

Computational study of ATP gated Potassium ion channel in urinary bladder over activity

Chitaranjan Mahapatra, Keith Brain, Rohit Manchanda

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.

Original language	English
Title of host publication	2016 International Conference on Inventive Computation Technologies (ICICT)
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	1-4
Number of pages	4
Volume	2016
ISBN (Electronic)	978-1-5090-1285-5
ISBN (Print)	978-1-5090-1286-2
DOIs	https://doi.org/10.1109/INVENTIVE.2016.7824861
Publication status	Published - 19 Jan 2017
Event	International Conference on Inventive Computer Technologies, 2016 - Coimbatore, India Duration: 26 Aug 2016 → 27 Aug 2016

Conference

Conference	International Conference on Inventive Computer Technologies, 2016
Abbreviated title	ICICT 2016
Country/Territory	India
City	Coimbatore
Period	26/08/16 → 27/08/16

ASJC Scopus subject areas

Computational Mathematics
Physiology

Access to Document

10.1109/INVENTIVE.2016.7824861

http://ieeexplore.ieee.org/document/7824861/

Validation of a computational model of urinary bladder electrical activity in health and during overactivity
Brain, K. (Principal Investigator)
BRITISH COUNCIL
16/03/12 → 15/01/15
Project: Other Government Departments

Cite this

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title = "Computational study of ATP gated Potassium ion channel in urinary bladder over activity",

abstract = "Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.",

author = "Chitaranjan Mahapatra and Keith Brain and Rohit Manchanda",

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pages = "1--4",

booktitle = "2016 International Conference on Inventive Computation Technologies (ICICT)",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

note = "International Conference on Inventive Computer Technologies, 2016, ICICT 2016 ; Conference date: 26-08-2016 Through 27-08-2016",

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Mahapatra, C, Brain, K & Manchanda, R 2017, Computational study of ATP gated Potassium ion channel in urinary bladder over activity. in 2016 International Conference on Inventive Computation Technologies (ICICT). vol. 2016, Institute of Electrical and Electronics Engineers (IEEE), pp. 1-4, International Conference on Inventive Computer Technologies, 2016, Coimbatore, India, 26/08/16. https://doi.org/10.1109/INVENTIVE.2016.7824861

Computational study of ATP gated Potassium ion channel in urinary bladder over activity. / Mahapatra, Chitaranjan; Brain, Keith; Manchanda, Rohit.
2016 International Conference on Inventive Computation Technologies (ICICT). Vol. 2016 Institute of Electrical and Electronics Engineers (IEEE), 2017. p. 1-4.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Computational study of ATP gated Potassium ion channel in urinary bladder over activity

AU - Mahapatra, Chitaranjan

AU - Brain, Keith

AU - Manchanda, Rohit

PY - 2017/1/19

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N2 - Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.

AB - Enhanced spontaneous electrical activity in detrusor smooth muscle cell is a major cause of over active bladder. ATP sensitive Potassium channel, which may play a crucial part in modulating resting membrane potential of detrusor smooth muscle cell and hence in bladder over activity. The main objective of our study is to construct a computational model of ATP sensitive Potassium channel in DSM cell with sufficient biophysical details to investigate its' modulating role in electrical excitability. The model was based on documented electrophysiological data in published experimental studies. We have validated our simulated ATP sensitive Potassium ion channel current by comparing with experimental recordings and it showed positive agreements in numerous parameters. At the present time, our computational model provides an elementary tool to analyze the physiological role of ATP sensitive Potassium ionic current in detrusor smooth muscle electrical activity underlying the contractions in DSM cells that successively will shed light in genesis of bladder overactivity.

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DO - 10.1109/INVENTIVE.2016.7824861

M3 - Conference contribution

SN - 978-1-5090-1286-2

VL - 2016

SP - 1

EP - 4

BT - 2016 International Conference on Inventive Computation Technologies (ICICT)

PB - Institute of Electrical and Electronics Engineers (IEEE)

T2 - International Conference on Inventive Computer Technologies, 2016

Y2 - 26 August 2016 through 27 August 2016

ER -

Computational study of ATP gated Potassium ion channel in urinary bladder over activity

Abstract

Conference

ASJC Scopus subject areas

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Validation of a computational model of urinary bladder electrical activity in health and during overactivity

Cite this