Computational neuropsychiatry - schizophrenia as a cognitive brain network disorder

Maria R. Dauvermann*, Heather C. Whalley, André Schmidt, Graham L. Lee, Liana Romaniuk, Neil Roberts, Eve C. Johnstone, Stephen M. Lawrie, Thomas W.J. Moorhead

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)
26 Downloads (Pure)

Abstract

Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia.

Original languageEnglish
Article numberArticle 30
JournalFrontiers in Psychiatry
Volume5
Issue numberMAR
DOIs
Publication statusPublished - 25 Mar 2014

Keywords

  • Cognition
  • Computational neuropsychiatry
  • Dopamine
  • Dynamic causal modeling
  • Fmri
  • Glutamate
  • Neurotransmitter
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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