Compromised GCF Total Antioxidant Capacity in Periodontitis - Cause or Effect?

Iain Chapple, Gareth Brock, Michael Milward, N Ling, John Matthews

Research output: Contribution to journalArticle

116 Citations (Scopus)


BACKGROUND: Oxidative stress is implicated in the pathogenesis of periodontitis. The total antioxidant capacity (TAOC) of gingival crevicular fluid volume (GCF) and plasma appears compromised in periodontitis, but it is unclear whether this predisposes to, or results from the inflammatory process. AIM: To investigate longitudinal changes in GCF and plasma TAOC following reductions in periodontal inflammation with successful non-surgical therapy. MATERIALS AND METHODS: Two longitudinal studies were run in series on non-smokers with chronic periodontitis (CP). Study-1 (n=17) assessed index sites with mild disease; Study-2 (n=18) investigated deep sites. GCF sampling and clinical measures were performed at baseline and 3 months post-therapy. Plasma and GCF TAOC was determined by enhanced chemiluminescence and 32 age/sex-matched periodontally healthy controls were used. RESULTS: Therapy improved clinical outcomes consistent with the literature. There were no differences in plasma TAOC between periodontitis patients (507+/-92 microMTeq) and controls (520+/-100 microMTeq; p=0.57) at baseline, but GCF TAOC was lower (p
Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalJournal of Clinical Periodontology
Publication statusPublished - 1 Feb 2007


  • gingival crevicular fluid
  • plasma
  • total antioxidant capacity
  • enhanced chemiluminescence
  • chronic periodontitis
  • non-surgical therapy


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