TY - JOUR
T1 - Compromised GCF Total Antioxidant Capacity in Periodontitis - Cause or Effect?
AU - Chapple, Iain
AU - Brock, Gareth
AU - Milward, Michael
AU - Ling, N
AU - Matthews, John
PY - 2007/2/1
Y1 - 2007/2/1
N2 - BACKGROUND: Oxidative stress is implicated in the pathogenesis of periodontitis. The total antioxidant capacity (TAOC) of gingival crevicular fluid volume (GCF) and plasma appears compromised in periodontitis, but it is unclear whether this predisposes to, or results from the inflammatory process. AIM: To investigate longitudinal changes in GCF and plasma TAOC following reductions in periodontal inflammation with successful non-surgical therapy. MATERIALS AND METHODS: Two longitudinal studies were run in series on non-smokers with chronic periodontitis (CP). Study-1 (n=17) assessed index sites with mild disease; Study-2 (n=18) investigated deep sites. GCF sampling and clinical measures were performed at baseline and 3 months post-therapy. Plasma and GCF TAOC was determined by enhanced chemiluminescence and 32 age/sex-matched periodontally healthy controls were used. RESULTS: Therapy improved clinical outcomes consistent with the literature. There were no differences in plasma TAOC between periodontitis patients (507+/-92 microMTeq) and controls (520+/-100 microMTeq; p=0.57) at baseline, but GCF TAOC was lower (p
AB - BACKGROUND: Oxidative stress is implicated in the pathogenesis of periodontitis. The total antioxidant capacity (TAOC) of gingival crevicular fluid volume (GCF) and plasma appears compromised in periodontitis, but it is unclear whether this predisposes to, or results from the inflammatory process. AIM: To investigate longitudinal changes in GCF and plasma TAOC following reductions in periodontal inflammation with successful non-surgical therapy. MATERIALS AND METHODS: Two longitudinal studies were run in series on non-smokers with chronic periodontitis (CP). Study-1 (n=17) assessed index sites with mild disease; Study-2 (n=18) investigated deep sites. GCF sampling and clinical measures were performed at baseline and 3 months post-therapy. Plasma and GCF TAOC was determined by enhanced chemiluminescence and 32 age/sex-matched periodontally healthy controls were used. RESULTS: Therapy improved clinical outcomes consistent with the literature. There were no differences in plasma TAOC between periodontitis patients (507+/-92 microMTeq) and controls (520+/-100 microMTeq; p=0.57) at baseline, but GCF TAOC was lower (p
KW - gingival crevicular fluid
KW - plasma
KW - total antioxidant capacity
KW - enhanced chemiluminescence
KW - chronic periodontitis
KW - non-surgical therapy
UR - http://www.scopus.com/inward/record.url?scp=33846340726&partnerID=8YFLogxK
U2 - 10.1111/j.1600-051X.2006.01029.x
DO - 10.1111/j.1600-051X.2006.01029.x
M3 - Article
C2 - 17214737
SN - 1600-051X
VL - 34
SP - 103
EP - 110
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
ER -