Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

Caitlin Hall; Katja Gehmlich; Chris Denning; Davor Pavlovic

doi:10.1161/JAHA.120.019338

Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

Caitlin Hall, Katja Gehmlich, Chris Denning, Davor Pavlovic

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

216 Downloads (Pure)

Abstract

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.

Original language	English
Article number	e019338
Number of pages	15
Journal	Journal of the American Heart Association
Volume	10
Issue number	5
Early online date	15 Feb 2021
DOIs	https://doi.org/10.1161/JAHA.120.019338
Publication status	Published - 2 Mar 2021

Bibliographical note

Funding Information:
This work was supported by the British Heart Foundation grants (PG/17/55/33087, RG/17/15/33106, FS/19/12/34204, and FS/19/16/34169 to Dr Pavlovic; SP/15/9/31605, PG/14/59/31000, RG/14/1/30588, RM/13/30157, and P47352/CRM to Dr Denning; and FS/12/40/29712 to Dr Gehmlich); the Wellcome Trust Grants (109604/Z/15/Z to Dr Pavlovic and 201543/B/16/Z to Dr Gehmlich); Animal Free Research UK (AFR19-20293 to Drs Pavlovic and Denning); National Centre for the Replacement, Refinement, and Reduction of Animals in Research (CRACK-IT:35911-259146 and NC/K000225/1 to Dr Denning and NC/T001747/1 to Dr Gehmlich); Accelerator Award (AA/18/2/34218) to Institute of Cardiovascular Sciences at Birmingham; and Oxford British Heart Foundation Centre of Research Excellence (RE/13/1/30181).

Publisher Copyright:
© 2021 The Authors.

Keywords

Arrhythmias
Cardiac fibroblasts
Cardiomyocytes
Fibrosis
Heart failure
Myofibroblast

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1161/JAHA.120.019338Licence: Creative Commons: Attribution (CC BY)

Hall_et_al_2021_Complex_relationship_between_cardiac_fibroblasts_Journal_of_the_American_Heart_AssociationFinal published version, 649 KBLicence: Creative Commons: Attribution (CC BY)

Investigating regulatory pathways for intracellular sodium in the atria
Pavlovic, D. (Principal Investigator) & Thomas, S. (Co-Investigator)
British Heart Foundation
1/10/19 → 30/04/23
Project: Research
Scarred by kidney disease: FGF23 as a key mediator of cardiac fibrosis in patients with chronic kidney disease
Weston, C. (Co-Investigator), Pavlovic, D. (Co-Investigator), McGettrick, H. (Co-Investigator) & Gough, R. (Principal Investigator)
British Heart Foundation
1/08/19 → 28/02/23
Project: Research
Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy
Arlt, W. (Co-Investigator), Pavlovic, D. (Principal Investigator), Taylor, A. (Co-Investigator), Kotecha, D. (Co-Investigator) & Kirchhof, P. (Co-Investigator)
British Heart Foundation
1/06/18 → 30/05/21
Project: Research
Examining the role of endogenous cardiotonic steriods in cardiovascular disease development.
Pavlovic, D. (Principal Investigator)
Wellcome Trust
1/04/16 → 31/03/18
Project: Research

Cite this

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Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Projects

Investigating regulatory pathways for intracellular sodium in the atria

Scarred by kidney disease: FGF23 as a key mediator of cardiac fibrosis in patients with chronic kidney disease

Cardiotonic steroids in patients with atrial fibrillation and heart failure: Quantification, functional effects and personalisation of digoxin therapy

Examining the role of endogenous cardiotonic steriods in cardiovascular disease development.

Cite this