Comparative MRI analysis of morphologic patterns of bile duct disease in IgG4-related systemic disease versus primary sclerosing cholangitis

Ajay Tokala, Korosh Khalili, Ravi Menezes, Gideon Hirschfield, Kartik S Jhaveri

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to perform a retrospective MRI-based comparative analysis of the morphologic patterns of bile duct disease in IgG4-related systemic disease (ISD, also called autoimmune pancreatitis) compared with primary sclerosing cholangitis (PSC) and the autoimmune liver diseases autoimmune hepatitis and primary biliary cirrhosis.

MATERIALS AND METHODS: This study included 162 consecutively registered patients (47 with ISD, 73 with PSC, and 42 with autoimmune liver diseases). Two abdominal radiologists retrospectively reviewed MR images in consensus. Imaging findings on the bile ducts, liver, pancreas, and other organs were analyzed to establish disease patterns.

RESULTS: ISD was associated with contiguous thickening of intrahepatic and extrahepatic bile ducts (p<0.001), pancreatic parenchymal abnormalities (p<0.001), renal abnormalities (p<0.001), and gallbladder wall thickening (p<0.03). The severity of common bile duct wall thickness was significantly different in ISD (p<0.001). The mean single wall thickness in the ISD group was 3.00 (SD, 1.47) mm, in the PSC group was 1.89 (SD, 0.73) mm, and in the autoimmune liver disease group was 1.80 (SD, 0.67) mm. PSC was associated with liver parenchymal abnormalities (p<0.001). We did not find statistical significance between the three groups in location (p=0.220) or length (p=0.703) of extrahepatic bile duct strictures, enhancement of bile duct stricture (p=0.033), upper abdominal lymphadenopathy, or retroperitoneal fibrosis. Although presence of intrahepatic bile duct stricture was statistically significant when all three groups were compared, it was not useful for differentiating ISD from PSC.

CONCLUSION: The presence of continuous as opposed to skip disease in the bile ducts, gallbladder involvement, and single-wall common bile duct thickness greater than 2.5 mm supports a diagnosis of ISD over PSC. ISD and PSC could not be differentiated on the basis of location and length of common bile duct stricture.

Original languageEnglish
Pages (from-to)536-543
Number of pages8
JournalAJR. American journal of roentgenology
Volume202
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Adult
  • Autoimmune Diseases
  • Bile Duct Diseases
  • Cholangitis, Sclerosing
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoglobulin G
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity
  • autoimmune pancreatitis
  • IgG4
  • primary sclerosing cholangitis
  • systemic disease

Fingerprint

Dive into the research topics of 'Comparative MRI analysis of morphologic patterns of bile duct disease in IgG4-related systemic disease versus primary sclerosing cholangitis'. Together they form a unique fingerprint.

Cite this