Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

M Linnebank; M Montenarh; H Kolsch; A Linnebank; K Schnez; D Schweichel; C Pohl; H Urbach; Reinhard Heun; U Harbrecht; T Klockgether; U Wullner

doi:10.1111/j.1468-1331.2005.01045.x

Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

M Linnebank, M Montenarh, H Kolsch, A Linnebank, K Schnez, D Schweichel, C Pohl, H Urbach, Reinhard Heun, U Harbrecht, T Klockgether, U Wullner

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.

Original language	English
Pages (from-to)	614-8
Number of pages	5
Journal	European Journal of Neurology
Volume	12
DOIs	https://doi.org/10.1111/j.1468-1331.2005.01045.x
Publication status	Published - 1 Aug 2005

Access to Document

10.1111/j.1468-1331.2005.01045.x

Cite this

@article{d6dd02ad11ef49e59844e13d264e46aa,

title = "Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study",

abstract = "Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.",

author = "M Linnebank and M Montenarh and H Kolsch and A Linnebank and K Schnez and D Schweichel and C Pohl and H Urbach and Reinhard Heun and U Harbrecht and T Klockgether and U Wullner",

year = "2005",

month = aug,

day = "1",

doi = "10.1111/j.1468-1331.2005.01045.x",

language = "English",

volume = "12",

pages = "614--8",

journal = "European Journal of Neurology",

issn = "1468-1331",

publisher = "Wiley",

}

TY - JOUR

T1 - Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

AU - Linnebank, M

AU - Montenarh, M

AU - Kolsch, H

AU - Linnebank, A

AU - Schnez, K

AU - Schweichel, D

AU - Pohl, C

AU - Urbach, H

AU - Heun, Reinhard

AU - Harbrecht, U

AU - Klockgether, T

AU - Wullner, U

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.

AB - Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.

UR - http://www.scopus.com/inward/record.url?scp=23644441339&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2005.01045.x

DO - 10.1111/j.1468-1331.2005.01045.x

M3 - Article

C2 - 16053469

SN - 1468-1331

VL - 12

SP - 614

EP - 618

JO - European Journal of Neurology

JF - European Journal of Neurology

ER -

Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

Abstract

Access to Document

Fingerprint

Cite this