Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Colorectal Tumour Gene Identification (CORGI) Consortium

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247 Citations (Scopus)

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P=4.44x10(-14)).
Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalNature Genetics
Volume40
Issue number1
Early online date16 Dec 2007
DOIs
Publication statusPublished - 1 Jan 2008

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