Combination dual responsive polypeptide vectors for enhanced gene delivery

Rujikan Nasanit; Parvez Iqbal; M Soliman; Neil Spencer; S Allen; M Davies; SS Briggs; L Seymour; Jon Preece

doi:10.1039/b803262a

Combination dual responsive polypeptide vectors for enhanced gene delivery

Rujikan Nasanit, Parvez Iqbal, M Soliman, Neil Spencer, S Allen, M Davies, SS Briggs, L Seymour, Jon Preece

Chemistry

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pKa vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pKa analogues.

Original language	English
Pages (from-to)	741-
Journal	Molecular BioSystems
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/b803262a
Publication status	Published - 1 Jan 2008

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title = "Combination dual responsive polypeptide vectors for enhanced gene delivery",

abstract = "Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pKa vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pKa analogues.",

author = "Rujikan Nasanit and Parvez Iqbal and M Soliman and Neil Spencer and S Allen and M Davies and SS Briggs and L Seymour and Jon Preece",

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AU - Nasanit, Rujikan

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AU - Soliman, M

AU - Spencer, Neil

AU - Allen, S

AU - Davies, M

AU - Briggs, SS

AU - Seymour, L

AU - Preece, Jon

PY - 2008/1/1

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N2 - Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pKa vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pKa analogues.

AB - Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pKa vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pKa analogues.

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DO - 10.1039/b803262a

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SN - 1742-2051

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SP - 741-

JO - Molecular BioSystems

JF - Molecular BioSystems

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Combination dual responsive polypeptide vectors for enhanced gene delivery

Abstract

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