TY - JOUR
T1 - Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis
AU - Vera, Alonso
AU - Gunson, BK
AU - Ussatoff, V
AU - Nightingale, Peter
AU - Candinas, Daniel
AU - Radley, Simon
AU - Mayer, Anthony
AU - Buckles, J
AU - McMaster, Paul
AU - Neuberger, James
AU - Mirza, Darius
PY - 2003/6/1
Y1 - 2003/6/1
N2 - BACKGROUND: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) may have an increased risk of developing colorectal cancer (CRC) after liver transplantation (LT). We evaluated our patients with PSC after LT to identify risk factors for CRC and its impact on survival. PATIENTS AND METHODS: A total of 152 patients (108 men, 100 with IBD) with PSC who underwent 173 LTs between 1986 and May 2000 were analyzed in three groups: (1) PSC without IBD (n=52); (2) PSC with colectomy (pre-LT and at LT) (n=17, colectomy pre-LT in 13 and simultaneous colectomy at LT in four); and (3) PSC with IBD and an intact colon (n=83). The following factors were studied: age, gender, liver, and renal biochemistry, international normalized ratio, Child-Pugh stage, operative time, blood use, hospital stay, immunosuppression, risk of CRC, retransplantation rate, and mortality. RESULTS: The incidence of CRC after LT was 5.3% (8/152) compared with 0.6% (7/1,184) in non-PSC cases (P
AB - BACKGROUND: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) may have an increased risk of developing colorectal cancer (CRC) after liver transplantation (LT). We evaluated our patients with PSC after LT to identify risk factors for CRC and its impact on survival. PATIENTS AND METHODS: A total of 152 patients (108 men, 100 with IBD) with PSC who underwent 173 LTs between 1986 and May 2000 were analyzed in three groups: (1) PSC without IBD (n=52); (2) PSC with colectomy (pre-LT and at LT) (n=17, colectomy pre-LT in 13 and simultaneous colectomy at LT in four); and (3) PSC with IBD and an intact colon (n=83). The following factors were studied: age, gender, liver, and renal biochemistry, international normalized ratio, Child-Pugh stage, operative time, blood use, hospital stay, immunosuppression, risk of CRC, retransplantation rate, and mortality. RESULTS: The incidence of CRC after LT was 5.3% (8/152) compared with 0.6% (7/1,184) in non-PSC cases (P
UR - http://www.scopus.com/inward/record.url?scp=0038451597&partnerID=8YFLogxK
U2 - 10.1097/01.TP.0000058744.34965.38
DO - 10.1097/01.TP.0000058744.34965.38
M3 - Article
C2 - 12829898
SN - 0041-1337
VL - 75
SP - 1983
EP - 1988
JO - Transplantation
JF - Transplantation
IS - 12
ER -
