Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Lisa Jones, Elizabeth Caesar, Katherine Gordon-Smith

Research output: Contribution to journalArticle

876 Citations (Scopus)

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Original languageEnglish
Pages (from-to)1056-1058
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 1 Sep 2008

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