Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Lisa Jones; Elizabeth Caesar; Katherine Gordon-Smith

doi:10.1038/ng.209

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Lisa Jones, Elizabeth Caesar, Katherine Gordon-Smith

Birmingham Medical School

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Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

Original language	English
Pages (from-to)	1056-1058
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/ng.209
Publication status	Published - 1 Sept 2008

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title = "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder",

abstract = "To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.",

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AB - To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Abstract

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