Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

Lucy Walker; A Gulbranson-Judge; S Flynn; T Brocker; Peter Lane

doi:10.1016/S0167-5699(00)01636-4

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

Lucy Walker
, A Gulbranson-Judge
, S Flynn
, T Brocker
, Peter Lane

Immunology and Immunotherapy

Research output: Contribution to journal › Article

74 Citations (Scopus)

Abstract

Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.

Original language	English
Pages (from-to)	333-7
Number of pages	5
Journal	Immunology Today
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/S0167-5699(00)01636-4
Publication status	Published - 1 Jul 2000

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title = "Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40",

abstract = "Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.",

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AU - Flynn, S

AU - Brocker, T

AU - Lane, Peter

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AB - Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.

UR - https://www.scopus.com/pages/publications/0007970554

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Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

Abstract

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