TY - JOUR
T1 - Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
AU - Walker, Lucy
AU - Gulbranson-Judge, A
AU - Flynn, S
AU - Brocker, T
AU - Lane, Peter
PY - 2000/7/1
Y1 - 2000/7/1
N2 - Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
AB - Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
UR - http://www.scopus.com/inward/record.url?scp=0007970554&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(00)01636-4
DO - 10.1016/S0167-5699(00)01636-4
M3 - Article
C2 - 10871874
SN - 1355-8242
VL - 21
SP - 333
EP - 337
JO - Immunology Today
JF - Immunology Today
IS - 7
ER -