Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

Shin-Yi Chiou; Ray-Yau Wang; Kwong-Kum Liao; Yu-Te Wu; Chia-Feng Lu; Yea-Ru Yang

doi:10.1016/j.clinph.2013.02.001

Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

Shin-Yi Chiou, Ray-Yau Wang, Kwong-Kum Liao, Yu-Te Wu, Chia-Feng Lu, Yea-Ru Yang

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

OBJECTIVE: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution.

METHODS: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD).

RESULTS: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions.

CONCLUSIONS: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation.

SIGNIFICANCE: The ipsilateral M1 plays a central role in unilateral motor executions.

Original language	English
Pages (from-to)	1353-63
Number of pages	11
Journal	Clinical Neurophysiology
Volume	124
Issue number	7
Early online date	7 Mar 2013
DOIs	https://doi.org/10.1016/j.clinph.2013.02.001
Publication status	Published - Jul 2013

Keywords

Adult
Analysis of Variance
Brain Mapping
Electromyography
Evoked Potentials, Motor
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Functional magnetic resonance imaging
Male
Motor Cortex
Movement
Muscle Contraction
Neural Inhibition
Oxygen
Principal Component Analysis
Recruitment, Neurophysiological
Transcranial Magnetic Stimulation
Young Adult
Journal Article
Research Support, Non-U.S. Gov't
Ipsilateral primary motor cortex co-activation
Interhemispheric inhibition
Homogeneous muscle

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title = "Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task",

abstract = "OBJECTIVE: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution.METHODS: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD).RESULTS: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions.CONCLUSIONS: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation.SIGNIFICANCE: The ipsilateral M1 plays a central role in unilateral motor executions.",

keywords = "Adult, Analysis of Variance, Brain Mapping, Electromyography, Evoked Potentials, Motor, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Functional magnetic resonance imaging, Male, Motor Cortex, Movement, Muscle Contraction, Neural Inhibition, Oxygen, Principal Component Analysis, Recruitment, Neurophysiological, Transcranial Magnetic Stimulation, Young Adult, Journal Article, Research Support, Non-U.S. Gov't, Ipsilateral primary motor cortex co-activation, Interhemispheric inhibition, Homogeneous muscle",

author = "Shin-Yi Chiou and Ray-Yau Wang and Kwong-Kum Liao and Yu-Te Wu and Chia-Feng Lu and Yea-Ru Yang",

year = "2013",

month = jul,

doi = "10.1016/j.clinph.2013.02.001",

language = "English",

volume = "124",

pages = "1353--63",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

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TY - JOUR

T1 - Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

AU - Chiou, Shin-Yi

AU - Wang, Ray-Yau

AU - Liao, Kwong-Kum

AU - Wu, Yu-Te

AU - Lu, Chia-Feng

AU - Yang, Yea-Ru

PY - 2013/7

Y1 - 2013/7

N2 - OBJECTIVE: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution.METHODS: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD).RESULTS: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions.CONCLUSIONS: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation.SIGNIFICANCE: The ipsilateral M1 plays a central role in unilateral motor executions.

AB - OBJECTIVE: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution.METHODS: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD).RESULTS: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions.CONCLUSIONS: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation.SIGNIFICANCE: The ipsilateral M1 plays a central role in unilateral motor executions.

KW - Adult

KW - Analysis of Variance

KW - Brain Mapping

KW - Electromyography

KW - Evoked Potentials, Motor

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Functional magnetic resonance imaging

KW - Male

KW - Motor Cortex

KW - Movement

KW - Muscle Contraction

KW - Neural Inhibition

KW - Oxygen

KW - Principal Component Analysis

KW - Recruitment, Neurophysiological

KW - Transcranial Magnetic Stimulation

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Ipsilateral primary motor cortex co-activation

KW - Interhemispheric inhibition

KW - Homogeneous muscle

U2 - 10.1016/j.clinph.2013.02.001

DO - 10.1016/j.clinph.2013.02.001

M3 - Article

C2 - 23478202

SN - 1388-2457

VL - 124

SP - 1353

EP - 1363

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 7

ER -

Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

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Keywords

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