Clinical presentations of Hepatitis E: A clinical review with representative case histories

Abhishek Chauhan, Gwilym Webb, James Ferguson

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5 Citations (Scopus)
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Hepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. This review examines current understanding of the HEV. We illustrate typical clinical presentations, management strategies [(based upon guidelines from both the British Transplant Society (BTS) and European Association for the study of liver (EASL)] and outcomes of HEV infection in different cohorts of patients by highlighting select transplant and non-transplant patient cases, from one of the largest tertiary Hepatology centres in Europe.

Original languageEnglish
Pages (from-to)649-657
Number of pages9
JournalClinics and Research in Hepatology and Gastroenterology
Issue number6
Early online date23 Feb 2019
Publication statusPublished - Nov 2019

Bibliographical note

Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.


  • Acute-on-chronic liver failure
  • Hepatitis E
  • acute decompensation
  • liver transplantation
  • viral hepatitis


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