Evaluation of: Kazumi K, Yasuyuki I, Kensaku S, Takeshi I, Shinji Y, Junya A. IV-tPA therapy in acute stroke patients with atrial fibrillation. J. Neurol. Sci. 276(1-2), 6-8 (2009). Stroke is the leading cause of disability and the second most common cause of death worldwide. The care and treatment of stroke patients have evolved over the last two decades, with increasing use of thrombolysis (e.g., intravenous tissue plasminogen activator in acute stroke patients), which has improved survival and recovery following stroke. The article under evaluation offers a greater insight into the relationship of clinical outcome of stroke and atrial fibrillation after tissue plasminogen activator infusion.