Of the 5883 patients studied, 83.6% (n=4920) were not on OAC and 16.4% (n=963) were taking OAC at the time of admission. There was no difference in mortality between patients on OAC vs no OAC prior to admission when compared in an adjusted multivariate analysis (HR1.05(95%CI 0.93-1.19),P=0.15) or in an adjusted propensity score analysis (HR0.92(95%CI0.58-1.450, P=0.18). In multivariate and adjusted propensity score analyses, the only significant association of no anticoagulation prior to diagnosis of COVID-19 was admission to ICU (HR1.98[95%CI1.37-2.85]). Thrombosis, MB, and MOF were associated with higher mortality. Our results indicate that patients may have benefit from prior OAC use especially reduced admission to ICU, without any increase in bleeding.
- coronavirus disease 2019
ASJC Scopus subject areas