Clinical impact of a high-frequency seizure onset zone in a case of bitemporal epilepsy

Premysl Jiruska, M Tomasek, D Netuka, J Otahal, John Jefferys, Xiaoli Li, P Marusic

Research output: Contribution to journalArticle

8 Citations (Scopus)


High-frequency activity has been described as having a role in the initiation of epileptic seizures. The case of a patient with refractory bitemporal epilepsy is presented. Extraoperative monitoring with depth and subdural electrodes revealed an ictal pattern with a build-up of high-frequency (> 80 Hz) activity originating in the cortex, with spread to both hippocampi. This observation was only revealed with the use of high-pass filtering, and represented crucial information that significantly influenced the decision about the side, localization and extent of resection. Removal of the cortex generating high-frequency activity, led to cessation of seizures in this patient. Current knowledge about the role of high-frequency activity and the case presented here support the importance of recording with equipment capable of detecting fast activity during the presurgical invasive monitoring. An active search for a high-frequency seizure onset zone in patients with structurally-unaffected hippocampi may improve the outcome beyond that possible with conventional bandwidth, invasive EEG recordings.
Original languageEnglish
Pages (from-to)231-8
Number of pages8
JournalEpileptic disorders : international epilepsy journal with videotape
Issue number3
Publication statusPublished - 1 Sept 2008


  • ictogenesis
  • bitemporal epilepsy
  • seizure onset zone
  • ictal high-frequency activity


Dive into the research topics of 'Clinical impact of a high-frequency seizure onset zone in a case of bitemporal epilepsy'. Together they form a unique fingerprint.

Cite this