Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Molebogeng X Rangaka; Lavanya Diwakar; Ronnett Seldon; Gilles van Cutsem; Graeme A Meintjes; Chelsea Morroni; Priscilla Mouton; Muki S Shey; Gary Maartens; Katalin A Wilkinson; Robert J Wilkinson; Lavanya Diwakar

doi:10.1086/518234

Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Molebogeng X Rangaka, Lavanya Diwakar, Ronnett Seldon, Gilles van Cutsem, Graeme A Meintjes, Chelsea Morroni, Priscilla Mouton, Muki S Shey, Gary Maartens, Katalin A Wilkinson, Robert J Wilkinson, Lavanya Diwakar

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

Original language	English
Pages (from-to)	1639-46
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	44
Issue number	12
DOIs	https://doi.org/10.1086/518234
Publication status	Published - 15 Jun 2007

Keywords

AIDS-Related Opportunistic Infections
Adult
Antigens, Bacterial
CD4 Lymphocyte Count
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections
Humans
Interferon-gamma
Male
Middle Aged
South Africa
T-Lymphocytes
Tuberculin Test
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1086/518234

Cite this

Rangaka, M. X., Diwakar, L., Seldon, R., van Cutsem, G., Meintjes, G. A., Morroni, C., Mouton, P., Shey, M. S., Maartens, G., Wilkinson, K. A., Wilkinson, R. J., & Diwakar, L. (2007). Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. Clinical Infectious Diseases, 44(12), 1639-46. https://doi.org/10.1086/518234

@article{3301d8e8806c4b3ea530de07b449f11e,

title = "Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans",

abstract = "Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.",

keywords = "AIDS-Related Opportunistic Infections, Adult, Antigens, Bacterial, CD4 Lymphocyte Count, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections, Humans, Interferon-gamma, Male, Middle Aged, South Africa, T-Lymphocytes, Tuberculin Test, Tuberculosis",

author = "Rangaka, {Molebogeng X} and Lavanya Diwakar and Ronnett Seldon and {van Cutsem}, Gilles and Meintjes, {Graeme A} and Chelsea Morroni and Priscilla Mouton and Shey, {Muki S} and Gary Maartens and Wilkinson, {Katalin A} and Wilkinson, {Robert J} and Lavanya Diwakar",

year = "2007",

month = jun,

day = "15",

doi = "10.1086/518234",

language = "English",

volume = "44",

pages = "1639--46",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "12",

}

Rangaka, MX, Diwakar, L, Seldon, R, van Cutsem, G, Meintjes, GA, Morroni, C, Mouton, P, Shey, MS, Maartens, G, Wilkinson, KA, Wilkinson, RJ & Diwakar, L 2007, 'Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans', Clinical Infectious Diseases, vol. 44, no. 12, pp. 1639-46. https://doi.org/10.1086/518234

TY - JOUR

T1 - Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

AU - Rangaka, Molebogeng X

AU - Diwakar, Lavanya

AU - Seldon, Ronnett

AU - van Cutsem, Gilles

AU - Meintjes, Graeme A

AU - Morroni, Chelsea

AU - Mouton, Priscilla

AU - Shey, Muki S

AU - Maartens, Gary

AU - Wilkinson, Katalin A

AU - Wilkinson, Robert J

AU - Diwakar, Lavanya

PY - 2007/6/15

Y1 - 2007/6/15

N2 - Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

AB - Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

KW - AIDS-Related Opportunistic Infections

KW - Adult

KW - Antigens, Bacterial

KW - CD4 Lymphocyte Count

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - HIV Infections

KW - Humans

KW - Interferon-gamma

KW - Male

KW - Middle Aged

KW - South Africa

KW - T-Lymphocytes

KW - Tuberculin Test

KW - Tuberculosis

U2 - 10.1086/518234

DO - 10.1086/518234

M3 - Article

C2 - 17516410

SN - 1058-4838

VL - 44

SP - 1639

EP - 1646

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this