Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma

Faisal S. BinHumaid; Anshita Goel; Naheema S. Gordon; Ben Abbotts; Benjamin J. Tura; K.K. Cheng; Maurice P. Zeegers; Nicholas D. James; Waleed Altaweel; Raouf Seyam; Mohammed Alotaibi; Roland Arnold; Douglas G. Ward; Richard T. Bryan

doi:10.1016/j.eururo.2025.11.007

Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma

Faisal S. BinHumaid
, Anshita Goel
, Naheema S. Gordon
, Ben Abbotts
, Benjamin J. Tura
, K.K. Cheng
, Maurice P. Zeegers
, Nicholas D. James
, Waleed Altaweel
, Raouf Seyam
, Mohammed Alotaibi
, Roland Arnold
, Douglas G. Ward
, Richard T. Bryan^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Original language	English
Number of pages	3
Journal	European urology
Early online date	3 Dec 2025
DOIs	https://doi.org/10.1016/j.eururo.2025.11.007
Publication status	E-pub ahead of print - 3 Dec 2025

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bladder Cancer
Non-muscle-invasive bladder cancer
high-throughput nucleotide sequencing
liquid biopsy

Access to Document

10.1016/j.eururo.2025.11.007Licence: None: All rights reserved

BinHumaidFS2025Circulating_AAMAccepted author manuscript, 176 KBLicence: Creative Commons: Attribution (CC BY)

The nascent role of circulating tumour DNA in the management of non-muscle-invasive bladder cancer
Bryan, R. T., Patel, K. & Ward, D. G., 16 Feb 2026, (Accepted/In press) In: BJU international.
Research output: Contribution to journal › Comment/debate › peer-review
The West Midlands Bladder Cancer Prognosis Programme: rationale and design.
Zeegers, M., Bryan, R., Langford, C., Billingham, L., Murray, P., Deshmukh, N., Hussain, S., James, N., Wallace, D. & Cheng, K., 14 Sept 2009, In: BJU international. 105, 6, p. 784-788 5 p.
Research output: Contribution to journal › Article
42 Citations (Scopus)

Bladder Cancer Prognosis Programme
Ward, D. (Co-Investigator), Bryan, R. (Principal Investigator) & Arnold, R. (Co-Investigator)
Cancer Research UK
1/09/22 → 30/06/24
Project: Research
Amplicon deep sequencing of Urinary DNA for the detection of bladder cancer: AmpseqUr
Ward, D. (Co-Investigator) & Bryan, R. (Principal Investigator)
Cancer Research UK
1/02/17 → 30/05/21
Project: Research

Cite this

BinHumaid, F. S., Goel, A., Gordon, N. S., Abbotts, B., Tura, B. J., Cheng, K. K., Zeegers, M. P., James, N. D., Altaweel, W., Seyam, R., Alotaibi, M., Arnold, R., Ward, D. G., & Bryan, R. T. (2025). Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma. European urology. Advance online publication. https://doi.org/10.1016/j.eururo.2025.11.007

@article{4b93a391d7ed4eafb48d0fd2640ed6b4,

title = "Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma",

keywords = "Bladder Cancer, Non-muscle-invasive bladder cancer, high-throughput nucleotide sequencing, liquid biopsy",

author = "BinHumaid, \{Faisal S.\} and Anshita Goel and Gordon, \{Naheema S.\} and Ben Abbotts and Tura, \{Benjamin J.\} and K.K. Cheng and Zeegers, \{Maurice P.\} and James, \{Nicholas D.\} and Waleed Altaweel and Raouf Seyam and Mohammed Alotaibi and Roland Arnold and Ward, \{Douglas G.\} and Bryan, \{Richard T.\}",

note = "Publisher Copyright: {\textcopyright} 2025 European Association of Urology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

year = "2025",

month = dec,

day = "3",

doi = "10.1016/j.eururo.2025.11.007",

language = "English",

journal = "European urology",

issn = "0302-2838",

publisher = "Elsevier",

}

TY - JOUR

T1 - Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma

AU - BinHumaid, Faisal S.

AU - Goel, Anshita

AU - Gordon, Naheema S.

AU - Abbotts, Ben

AU - Tura, Benjamin J.

AU - Cheng, K.K.

AU - Zeegers, Maurice P.

AU - James, Nicholas D.

AU - Altaweel, Waleed

AU - Seyam, Raouf

AU - Alotaibi, Mohammed

AU - Arnold, Roland

AU - Ward, Douglas G.

AU - Bryan, Richard T.

PY - 2025/12/3

Y1 - 2025/12/3

KW - Bladder Cancer

KW - Non-muscle-invasive bladder cancer

KW - high-throughput nucleotide sequencing

KW - liquid biopsy

U2 - 10.1016/j.eururo.2025.11.007

DO - 10.1016/j.eururo.2025.11.007

M3 - Letter

C2 - 41344931

SN - 0302-2838

JO - European urology

JF - European urology

ER -

Circulating Tumour DNA Positivity Predicts Shorter Survival for Patients with High-grade pT1 Urothelial Bladder Carcinoma

Bibliographical note

UN SDGs

Keywords

Access to Document

Research output

The nascent role of circulating tumour DNA in the management of non-muscle-invasive bladder cancer

The West Midlands Bladder Cancer Prognosis Programme: rationale and design.

Projects

Bladder Cancer Prognosis Programme

Amplicon deep sequencing of Urinary DNA for the detection of bladder cancer: AmpseqUr

Cite this