Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

Karl Payne; Rachel Spruce; Andrew Beggs; Neil Sharma; Anthony Kong; Timothy Martin; Satyesh Parmar; Prav Praveen; Paul Nankivell; Hisham Mehanna

doi:10.1002/hed.25140

Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

Karl Payne, Rachel Spruce, Andrew Beggs, Neil Sharma, Anthony Kong, Timothy Martin, Satyesh Parmar, Prav Praveen, Paul Nankivell, Hisham Mehanna

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Abstract

The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).

Original language	English
Pages (from-to)	1598-1604
Number of pages	7
Journal	Head & Neck
Volume	40
Issue number	7
Early online date	15 Mar 2018
DOIs	https://doi.org/10.1002/hed.25140
Publication status	Published - 1 Jul 2018

Bibliographical note

Payne K, Spruce R, Beggs A, et al. Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma. Head & Neck. 2018;40:1598–1604. https://doi.org/10.1002/hed.25140

Keywords

Journal Article
biomarker
circulating tumor DNA (ctDNA)
head and neck cancer
liquid biopsy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Payne_et_al_Circulating_tumor_DNA_Head_&_Neck_2018
Published in Head & Neck on 15/03/2018 DOI: 10.1002/hed.25140
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https://onlinelibrary.wiley.com/doi/full/10.1002/hed.25140Licence: Creative Commons: Attribution (CC BY)

Cite this

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abstract = "The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).",

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AU - Martin, Timothy

AU - Parmar, Satyesh

AU - Praveen, Prav

AU - Nankivell, Paul

AU - Mehanna, Hisham

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Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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