TY - JOUR
T1 - Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease
AU - Patel, Jeetesh
AU - Abraheem, A
AU - Chackathayil, Julia
AU - Gunning, M
AU - Creamer, J
AU - Hughes, Elizabeth
AU - Lip, Gregory
PY - 2009/5/1
Y1 - 2009/5/1
N2 - BACKGROUND: Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) are often asymptomatic. Angiogenesis is implicated in the physiology of vascular repair and cardiac remodelling, and is one of many pathophysiological processes implicated in heart failure. We hypothesized that plasma indices associated with angiogenesis [angiogenin, vascular endothelial growth factor (VEGF), and angiopoietin (Ang)-1 and Ang-2] would be abnormal in CAD patients with LVSD, being correlated with EF and wall motion abnormalities (wall motion score) independently of underlying CAD (coronary atheroma score). We also evaluated the specificity of angiogenic 'biomarkers' in their detection of LVSD [ejection fraction (EF)
AB - BACKGROUND: Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) are often asymptomatic. Angiogenesis is implicated in the physiology of vascular repair and cardiac remodelling, and is one of many pathophysiological processes implicated in heart failure. We hypothesized that plasma indices associated with angiogenesis [angiogenin, vascular endothelial growth factor (VEGF), and angiopoietin (Ang)-1 and Ang-2] would be abnormal in CAD patients with LVSD, being correlated with EF and wall motion abnormalities (wall motion score) independently of underlying CAD (coronary atheroma score). We also evaluated the specificity of angiogenic 'biomarkers' in their detection of LVSD [ejection fraction (EF)
U2 - 10.1111/j.1365-2796.2008.02057.x
DO - 10.1111/j.1365-2796.2008.02057.x
M3 - Article
C2 - 19187100
SN - 1365-2796
VL - 265
SP - 562
EP - 567
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 5
ER -