Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study

Ahmad M. Osailan; George S. Metsios; Joan L. Duda; George D. Kitas; Jet J. C. S. Veldhuijzen van Zanten; Ragab K. Elnaggar

doi:10.3390/jcm12237256

Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study

Ahmad M. Osailan^*
, George S. Metsios
, Joan L. Duda
, George D. Kitas
, Jet J. C. S. Veldhuijzen van Zanten
, Ragab K. Elnaggar

^*Corresponding author for this work

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Individuals with rheumatoid arthritis (RA) are at a high risk of cardiovascular diseases (CVD). A reduced chronotropic response (CR), which produces exercise intolerance, is known to be a contributing factor to CVD and mortality. Studies have shown that patients with RA have a reduced CR. However, knowledge of CR-related factors in patients with RA is limited. This study aimed to explore CR-related factors, including CVD risk factors, inflammatory markers, and cardiorespiratory fitness (VO_2PEAK).

Methods: A total of 106 RA patients underwent a treadmill test, heart rate monitoring, and various assessments, including serological CVD risk factors, inflammatory markers, and VO_2PEAK.

Results: A total of 34% of participants demonstrated a reduced CR (≤80%). Body mass index, HOMA, hsCRP, and fibrinogen were inversely related to CR, while HDL, QUICKi, VO_2PEAK, and RER exhibited a positive association. HDL and VO_2PEAK emerged as independent CR-related factors in regression analysis.

Conclusions: The current findings suggest that reduced CR in RA is associated with several CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.

Original language	English
Article number	7256
Number of pages	12
Journal	Journal of Clinical Medicine
Volume	12
Issue number	23
Early online date	23 Nov 2023
DOIs	https://doi.org/10.3390/jcm12237256
Publication status	Published - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cardiovascular diseases
chronotropic response
exercise testing
rheumatoid arthritis

ASJC Scopus subject areas

General Medicine

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OsailanAM2023ChronotropicFinal published version, 633 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

@article{e9b4e190c6da45c79bb8ee5b740df3fb,

title = "Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study",

abstract = "Background: Individuals with rheumatoid arthritis (RA) are at a high risk of cardiovascular diseases (CVD). A reduced chronotropic response (CR), which produces exercise intolerance, is known to be a contributing factor to CVD and mortality. Studies have shown that patients with RA have a reduced CR. However, knowledge of CR-related factors in patients with RA is limited. This study aimed to explore CR-related factors, including CVD risk factors, inflammatory markers, and cardiorespiratory fitness (VO2PEAK). Methods: A total of 106 RA patients underwent a treadmill test, heart rate monitoring, and various assessments, including serological CVD risk factors, inflammatory markers, and VO2PEAK. Results: A total of 34\% of participants demonstrated a reduced CR (≤80\%). Body mass index, HOMA, hsCRP, and fibrinogen were inversely related to CR, while HDL, QUICKi, VO2PEAK, and RER exhibited a positive association. HDL and VO2PEAK emerged as independent CR-related factors in regression analysis. Conclusions: The current findings suggest that reduced CR in RA is associated with several CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.",

keywords = "cardiovascular diseases, chronotropic response, exercise testing, rheumatoid arthritis",

author = "Osailan, \{Ahmad M.\} and Metsios, \{George S.\} and Duda, \{Joan L.\} and Kitas, \{George D.\} and \{Veldhuijzen van Zanten\}, \{Jet J. C. S.\} and Elnaggar, \{Ragab K.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = dec,

doi = "10.3390/jcm12237256",

language = "English",

volume = "12",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "MDPI",

number = "23",

}

TY - JOUR

T1 - Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis

T2 - A Cross-Sectional Study

AU - Osailan, Ahmad M.

AU - Metsios, George S.

AU - Duda, Joan L.

AU - Kitas, George D.

AU - Veldhuijzen van Zanten, Jet J. C. S.

AU - Elnaggar, Ragab K.

PY - 2023/12

Y1 - 2023/12

N2 - Background: Individuals with rheumatoid arthritis (RA) are at a high risk of cardiovascular diseases (CVD). A reduced chronotropic response (CR), which produces exercise intolerance, is known to be a contributing factor to CVD and mortality. Studies have shown that patients with RA have a reduced CR. However, knowledge of CR-related factors in patients with RA is limited. This study aimed to explore CR-related factors, including CVD risk factors, inflammatory markers, and cardiorespiratory fitness (VO2PEAK). Methods: A total of 106 RA patients underwent a treadmill test, heart rate monitoring, and various assessments, including serological CVD risk factors, inflammatory markers, and VO2PEAK. Results: A total of 34% of participants demonstrated a reduced CR (≤80%). Body mass index, HOMA, hsCRP, and fibrinogen were inversely related to CR, while HDL, QUICKi, VO2PEAK, and RER exhibited a positive association. HDL and VO2PEAK emerged as independent CR-related factors in regression analysis. Conclusions: The current findings suggest that reduced CR in RA is associated with several CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.

AB - Background: Individuals with rheumatoid arthritis (RA) are at a high risk of cardiovascular diseases (CVD). A reduced chronotropic response (CR), which produces exercise intolerance, is known to be a contributing factor to CVD and mortality. Studies have shown that patients with RA have a reduced CR. However, knowledge of CR-related factors in patients with RA is limited. This study aimed to explore CR-related factors, including CVD risk factors, inflammatory markers, and cardiorespiratory fitness (VO2PEAK). Methods: A total of 106 RA patients underwent a treadmill test, heart rate monitoring, and various assessments, including serological CVD risk factors, inflammatory markers, and VO2PEAK. Results: A total of 34% of participants demonstrated a reduced CR (≤80%). Body mass index, HOMA, hsCRP, and fibrinogen were inversely related to CR, while HDL, QUICKi, VO2PEAK, and RER exhibited a positive association. HDL and VO2PEAK emerged as independent CR-related factors in regression analysis. Conclusions: The current findings suggest that reduced CR in RA is associated with several CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.

KW - cardiovascular diseases

KW - chronotropic response

KW - exercise testing

KW - rheumatoid arthritis

UR - https://www.scopus.com/pages/publications/85179320262

U2 - 10.3390/jcm12237256

DO - 10.3390/jcm12237256

M3 - Article

AN - SCOPUS:85179320262

SN - 2077-0383

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 23

M1 - 7256

ER -

Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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