Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

Sharon Hughes; RA Shiner; Margaret Smith

doi:10.1016/S0006-8993(00)03055-9

Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

Sharon Hughes
, RA Shiner
, Margaret Smith

Birmingham Medical School

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.

Original language	English
Pages (from-to)	191-193
Number of pages	3
Journal	Brain Research
Volume	887
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(00)03055-9
Publication status	Published - 1 Dec 2000

Keywords

motoneuron
exercise
pro-opiomelanocortin
beta-endorphin
nerve stimulation

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10.1016/S0006-8993(00)03055-9

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title = "Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones",

abstract = "Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.",

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T1 - Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

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AU - Shiner, RA

AU - Smith, Margaret

PY - 2000/12/1

Y1 - 2000/12/1

N2 - Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.

AB - Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.

KW - motoneuron

KW - exercise

KW - pro-opiomelanocortin

KW - beta-endorphin

KW - nerve stimulation

U2 - 10.1016/S0006-8993(00)03055-9

DO - 10.1016/S0006-8993(00)03055-9

M3 - Article

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JO - Brain Research

JF - Brain Research

IS - 1

ER -

Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

Abstract

Keywords

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