Chimeric antigen receptor

Steven Lee (Inventor), Roy Bicknell (Inventor), Michaela Sharpe (Inventor), Natalie Mount (Inventor)

Research output: Patent


The present invention is directed to a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric antigen receptor comprising (a) an anti-CLEC14A binding domain, (b) a transmembrane domain and (c) an intracellular signalling domain; wherein said anti-CLEC14A binding domain is capable of binding to the C- type lectin domain of CLEC14A. The invention further provides a chimeric antigen receptor encoded by the nucleic acid molecule, a vector comprising the nucleic acid molecule, a cell comprising the nucleic acid molecule, vector or CAR and the therapeutic use of the nucleic acid, vector or cell, particularly in treating CLEC14A expressing conditions.
Original languageEnglish
Patent numberWO2017158337
Publication statusPublished - 21 Sept 2017


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