Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro-odontosarcoma of the maxilla

Susanne A Gatz, Khin Thway, Henry Mandeville, Cyrus Kerawala, David MacVicar, Julia Chisholm

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7 Citations (Scopus)
111 Downloads (Pure)

Abstract

Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS.

Original languageEnglish
Pages (from-to)2029-2032
Number of pages4
JournalPediatric Blood & Cancer
Volume62
Issue number11
Early online date15 Jul 2015
DOIs
Publication statusPublished - Nov 2015

Keywords

  • Ameloblastoma/surgery
  • Child
  • Female
  • Fibrosarcoma/surgery
  • Humans
  • Maxillary Neoplasms/surgery
  • Neoplasm Recurrence, Local/surgery
  • Radiosurgery
  • Remission Induction

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