Chemokines: leucocyte recruitment and activation cytokines

A R Lloyd, David Adams

Research output: Contribution to journalArticlepeer-review

407 Citations (Scopus)


Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the generation of cellular inflammation, both in the protective responses to invading pathogens and in the pathological processes associated with infection and immune-mediated diseases. Chemokines are more than simple chemotactic factors, since they are also implicated in leucocyte activation, angiogenesis, and antimicrobial functions, including a protective role in HIV infection. These molecules provide potentially valuable targets for therapeutic intervention in a wide range of diseases.
Original languageEnglish
Pages (from-to)490-5
Number of pages6
Issue number9050
Publication statusPublished - 15 Feb 1997


  • Chemokines
  • Chemotactic Factors
  • Chemotaxis, Leukocyte
  • Cytokines
  • HIV Infections
  • Humans
  • Inflammation Mediators
  • Leukocytes


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