Chemoenzymatic synthesis of feruloyl d-arabinose as a potential anti-mycobacterial agent

C Vafiadi; E Topakas; Luke Alderwick; Gurdyal Besra; P Christakopoulos

doi:10.1007/s10529-007-9440-4

Chemoenzymatic synthesis of feruloyl d-arabinose as a potential anti-mycobacterial agent

C Vafiadi, E Topakas, Luke Alderwick, Gurdyal Besra, P Christakopoulos

Biosciences

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17 Citations (Scopus)

Abstract

The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to D: -arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of D: -arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 microg/ml.

Original language	English
Pages (from-to)	1771-1774
Number of pages	4
Journal	Biotechnology Letters
Volume	29
Issue number	11
Early online date	4 Aug 2007
DOIs	https://doi.org/10.1007/s10529-007-9440-4
Publication status	Published - 27 Sept 2007

Keywords

mycobacteria
feruloyl esterase
enzymatic transesterification

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10.1007/s10529-007-9440-4

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abstract = "The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to D: -arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of D: -arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 microg/ml.",

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AU - Vafiadi, C

AU - Topakas, E

AU - Alderwick, Luke

AU - Besra, Gurdyal

AU - Christakopoulos, P

PY - 2007/9/27

Y1 - 2007/9/27

N2 - The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to D: -arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of D: -arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 microg/ml.

AB - The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to D: -arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of D: -arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 microg/ml.

KW - mycobacteria

KW - feruloyl esterase

KW - enzymatic transesterification

U2 - 10.1007/s10529-007-9440-4

DO - 10.1007/s10529-007-9440-4

M3 - Article

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SN - 1573-6776

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EP - 1774

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 11

ER -

Chemoenzymatic synthesis of feruloyl d-arabinose as a potential anti-mycobacterial agent

Abstract

Keywords

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