Chemical and mechanical modulation of polymeric micelle assembly

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6 Citations (Scopus)


Recently, polymeric micelles self-assembled from amphiphilic polymers have been studied for various industrial and biomedical applications. This nanoparticle self-assembly typically occurs in a solvent- exchange process. In this process, the quality of the resulting particles is uncontrollably mediated by poly- meric solubility and mixing conditions. Here, we hypothesized that improving the solubility of an amphi- philic polymer in an organic solvent via chemical modification while controlling the mixing rate of organic and aqueous phases would enhance control over particle morphology and size. We examined this hypothesis by synthesizing a poly(2-hydroxyethyl)aspartamide (PHEA) grafted with controlled numbers of octadecyl (C18) chains and oligovaline groups (termed “oligovaline-PHEA-C18”). The mixing rate of DMF and water was controlled either by microfluidic mixing of laminar DMF and water flows or through turbu- lent bulk mixing. Interestingly, oligovaline-PHEA-C18 exhibited an increased solubility in DMF compared with PHEA-C18, as demonstrated by an increase of mixing energy. In addition, increasing the mixing rate between water and DMF using the microfluidic mixer resulted in a decrease of the diameter of the result- ing polymeric micelles, as compared with the particles formed from a bulk mixing process. Overall, these findings will expand the parameter space available to control particle self-assembly while also serving to improve existing nanoparticle processing techniques.
Original languageEnglish
Publication statusPublished - 11 Apr 2017


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