Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions

Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson*, Stephen M. Goldup

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Although metal-ion-binding interlocked molecules have been under intense investigation for over three decades, their application as scaffolds for the development of sensors for metal ions remains underexplored. In this work, we demonstrate the potential of simple rotaxanes as metal-ion-responsive ligand scaffolds through the development of a proof-of-concept selective sensor for Zn2+.

Original languageEnglish
Pages (from-to)5310-5314
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number19
Publication statusPublished - 4 May 2018

Bibliographical note

Funding Information:
K.J. and J.P. contributed equally. M.D. thanks the University of Southampton and EPSRC (EP/L505067/1) for financial support. K.J. thanks QMUL for financial support. J.P. thanks the EPSRC for financial support. S.M.G acknowledges funding from the European Research Council (Consolidator Grant Agreement no. 724987). S.M.G thanks the Royal Society for aResearch Fellowship. M.W. acknowledges COST Action TD1304 Zinc-Net. We are grateful to the EPSRC UK National Mass Spectrometry Facility (NMSF) for high resolution mass spectrometry.

Publisher Copyright:
© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.


  • fluorescent probes
  • rotaxanes
  • sensors
  • supramolecular chemistry
  • zinc

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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