Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.

Arun Kumar Mishra; Sarah Batt; K Krumbach; L Eggeling; Gurdyal Besra

doi:10.1128/JB.01729-08

Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.

Arun Kumar Mishra
, Sarah Batt
, K Krumbach
, L Eggeling
, Gurdyal Besra

Biosciences

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

In this study, utilizing a Corynebacterium glutamicum DeltapimB' DeltamgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac(1)PIM(1):mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2):mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimB(Mt) and MgtA(Mt), respectively, in Mycobacterium tuberculosis.

Original language	English
Pages (from-to)	4465-72
Number of pages	8
Journal	Journal of Bacteriology
Volume	191
Issue number	13
DOIs	https://doi.org/10.1128/JB.01729-08
Publication status	Published - 1 Jul 2009

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SDG 3 Good Health and Well-being

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10.1128/JB.01729-08

The structure and role of antigenic glycolipids in the mycobacterium tuberculosis complex
Besra, D. (Principal Investigator), Lammas, T. (Co-Investigator) & Minnikin, D. (Co-Investigator)
Medical Research Council
1/09/03 → 31/08/06
Project: Research Councils

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title = "Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.",

abstract = "In this study, utilizing a Corynebacterium glutamicum DeltapimB' DeltamgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac(1)PIM(1):mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2):mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimB(Mt) and MgtA(Mt), respectively, in Mycobacterium tuberculosis.",

author = "Mishra, \{Arun Kumar\} and Sarah Batt and K Krumbach and L Eggeling and Gurdyal Besra",

year = "2009",

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doi = "10.1128/JB.01729-08",

language = "English",

volume = "191",

pages = "4465--72",

journal = "Journal of Bacteriology",

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Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis. / Mishra, Arun Kumar; Batt, Sarah; Krumbach, K et al.
In: Journal of Bacteriology, Vol. 191, No. 13, 01.07.2009, p. 4465-72.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.

AU - Mishra, Arun Kumar

AU - Batt, Sarah

AU - Krumbach, K

AU - Eggeling, L

AU - Besra, Gurdyal

PY - 2009/7/1

Y1 - 2009/7/1

N2 - In this study, utilizing a Corynebacterium glutamicum DeltapimB' DeltamgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac(1)PIM(1):mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2):mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimB(Mt) and MgtA(Mt), respectively, in Mycobacterium tuberculosis.

AB - In this study, utilizing a Corynebacterium glutamicum DeltapimB' DeltamgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac(1)PIM(1):mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2):mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimB(Mt) and MgtA(Mt), respectively, in Mycobacterium tuberculosis.

U2 - 10.1128/JB.01729-08

DO - 10.1128/JB.01729-08

M3 - Article

C2 - 19395496

VL - 191

SP - 4465

EP - 4472

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 13

ER -

Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.

Abstract

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The structure and role of antigenic glycolipids in the mycobacterium tuberculosis complex

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