Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor

Jamie Birch, Nicholas Juleff, Michael P Heaton, Ted Kalbfleisch, James Kijas, Dalan Bailey

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.
Original languageEnglish
Pages (from-to)4756-61
Number of pages6
JournalJournal of virology
Issue number8
Publication statusPublished - Apr 2013


  • Peste-des-petits-ruminants virus
  • Animals
  • Virus Attachment
  • Receptors, Virus
  • Epithelial Cells
  • Sheep
  • Cell Adhesion Molecules


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