Characterisation of 11 -hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

Iwona Bujalska; Omar Durrani; Joseph Abbott; CU Onyimba; Pamela Khosla; AH Moosavi; Tristan Reuser; Paul Stewart; Jeremy Tomlinson; Elizabeth Walker; Saaeha Rauz

doi:10.1677/JOE-06-0042

Characterisation of 11 -hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

Iwona Bujalska, Omar Durrani, Joseph Abbott, CU Onyimba, Pamela Khosla, AH Moosavi, Tristan Reuser, Paul Stewart, Jeremy Tomlinson, Elizabeth Walker, Saaeha Rauz

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25 Citations (Scopus)

Abstract

Glucocorticoids (GCs) have a profound effect on adipose biology increasing tissue mass causing central obesity. The pre-receptor regulation of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) that activates cortisol from cortisone has been postulated as a fundamental mechanism underlying the metabolic syndrome mediating adipocyte hyperplasia and hypertrophy in the omental (OM) depot. Orbital adipose tissue (OF) is the site of intense inflammation and tissue remodelling in several orbital inflammatory disease states. In this study, we describe features of the GC metabolic pathways in normal human OF depot and compare it with subcutaneous (SC) and OM depots. Using an automated histological characterisation technique, OF adipocytes were found to be significantly smaller (parameters: area, maximum diameter and perimeter) than OM and SC adipocytes (P

Original language	English
Pages (from-to)	279-88
Number of pages	10
Journal	Journal of Endocrinology
Volume	192
Issue number	2
DOIs	https://doi.org/10.1677/JOE-06-0042
Publication status	Published - 1 Feb 2007

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10.1677/JOE-06-0042

Pre-receptor Metabolism and the Control of Hormone Action
Stewart, P.
Medical Research Council
1/12/02 → 31/05/08
Project: Research Councils

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abstract = "Glucocorticoids (GCs) have a profound effect on adipose biology increasing tissue mass causing central obesity. The pre-receptor regulation of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) that activates cortisol from cortisone has been postulated as a fundamental mechanism underlying the metabolic syndrome mediating adipocyte hyperplasia and hypertrophy in the omental (OM) depot. Orbital adipose tissue (OF) is the site of intense inflammation and tissue remodelling in several orbital inflammatory disease states. In this study, we describe features of the GC metabolic pathways in normal human OF depot and compare it with subcutaneous (SC) and OM depots. Using an automated histological characterisation technique, OF adipocytes were found to be significantly smaller (parameters: area, maximum diameter and perimeter) than OM and SC adipocytes (P",

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AU - Bujalska, Iwona

AU - Durrani, Omar

AU - Abbott, Joseph

AU - Onyimba, CU

AU - Khosla, Pamela

AU - Moosavi, AH

AU - Reuser, Tristan

AU - Stewart, Paul

AU - Tomlinson, Jeremy

AU - Walker, Elizabeth

AU - Rauz, Saaeha

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Characterisation of 11 -hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

Abstract

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Pre-receptor Metabolism and the Control of Hormone Action

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