Changing indications for a total pancreatectomy: perspectives over a quarter of a century

Max Almond, Keith J Roberts, James Hodson, Robert Sutcliffe, Ravi Marudanayagam, John Isaac, Paolo Muiesan, Darius Mirza

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)
60 Downloads (Pure)


INTRODUCTION: The indications for a total pancreatectomy (TP), its peri-operative management, provision of pancreatic surgical services and medical treatment of the inherent exo- and endocrine deficient states have all changed considerably over recent decades. The effects of these upon the incidence, indications for and outcomes of TP are unclear. Patients undergoing TP at a single institution over a quarter of a century were reviewed to try to address these issues.

METHODS: Data on patients who underwent elective (el-) and emergency TP (em-TP) between 1987 and 2013 were reviewed. Patient demographics, indications, intra-operative details, peri-operative management and long-term outcomes were analysed. Absolute numbers of TP were reported relative to partial pancreatectomy rates.

RESULTS: In total, 136 patients underwent TP [98 (72.1%) el-TP; 38 (27.9%) em-TP]. There was a significant change in indication for el-TP with it increasingly performed for (an intraductal papillary mucinous neoplasm (IPMN) and renal cell metastases whereas there was a decrease in the number of el-TP performed for chronic pancreatitis (P = 0.025). The relative rates of el-TP, however, did not change significantly across the study period (P = 0.225). The median length of stay after el-TP decreased from 19 days pre-1997 to 12 days post-1997 (P = 0.009). The relative use of em-TP declined by 0.28 percentage points per year [P = 0.018; 95% confidence interval (CI): 0.04-0.41].

CONCLUSIONS: The indications for el-TP have changed; it is being performed more frequently although the proportion relative to other pancreatic resections has not changed. A decrease in the rate of em-TP is likely to reflect improved peri-operative management of a pancreatic fistula and its complications after a pancreaticoduodenectomy.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalHPB : the official journal of the International Hepato Pancreato Biliary Association
Issue number5
Publication statusPublished - May 2015


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Decision Making
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatectomy
  • Pancreatic Diseases
  • Retrospective Studies
  • Young Adult


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