Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

Anna Price; George Greenhall; William Moody; Richard Steeds; Patrick B Mark; Nicky Edwards; Manvir Hayer; Luke Pickup; Ashwin Radhakrishnan; Jonathan Law; Debasish Banerjee; Tunde Campbell; Charles Tomson; John Cockcroft; Badri Shrestha; Ian B Wilkinson; Laurie  Tomlinson; Charles Ferro; Jon Townend

doi:10.2215/CJN.15651219

Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

Anna Price, George Greenhall, William Moody, Richard Steeds, Patrick B Mark, Nicky Edwards, Manvir Hayer, Luke Pickup, Ashwin Radhakrishnan, Jonathan Law, Debasish Banerjee, Tunde Campbell, Charles Tomson, John Cockcroft, Badri Shrestha, Ian B Wilkinson, Laurie Tomlinson, Charles Ferro, Jon Townend

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Abstract

BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months.

RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m 2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49).

CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls.

CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).

Original language	English
Pages (from-to)	1330-1339
Number of pages	10
Journal	Clinical Journal of the American Society of Nephrology
Volume	15
Issue number	9
DOIs	https://doi.org/10.2215/CJN.15651219
Publication status	Published - 7 Sept 2020

Bibliographical note

ASJC Scopus subject areas

Epidemiology
Critical Care and Intensive Care Medicine
Nephrology
Transplantation

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10.2215/CJN.15651219Licence: None: All rights reserved

EARNEST-FINAL-cjasn_Clean_May2020Accepted author manuscript, 646 KBLicence: None: All rights reserved
Figure 2_1000dpiFinal published version, 190 KBLicence: None: All rights reserved
Supplemental_cjasn_clean_May2020Other version, 455 KBLicence: None: All rights reserved
Figure 1_1000dpiOther version, 33.9 KBLicence: None: All rights reserved

Cite this

Price, A., Greenhall, G., Moody, W., Steeds, R., Mark, P. B., Edwards, N., Hayer, M., Pickup, L., Radhakrishnan, A., Law, J., Banerjee, D., Campbell, T., Tomson, C., Cockcroft, J., Shrestha, B., Wilkinson, I. B., Tomlinson, L., Ferro, C., & Townend, J. (2020). Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation. Clinical Journal of the American Society of Nephrology, 15(9), 1330-1339. https://doi.org/10.2215/CJN.15651219

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title = "Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation",

abstract = "BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months.RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m 2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49). CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).",

author = "Anna Price and George Greenhall and William Moody and Richard Steeds and Mark, {Patrick B} and Nicky Edwards and Manvir Hayer and Luke Pickup and Ashwin Radhakrishnan and Jonathan Law and Debasish Banerjee and Tunde Campbell and Charles Tomson and John Cockcroft and Badri Shrestha and Wilkinson, {Ian B} and Laurie Tomlinson and Charles Ferro and Jon Townend",

note = "Copyright {\textcopyright} 2020 by the American Society of Nephrology.",

year = "2020",

month = sep,

day = "7",

doi = "10.2215/CJN.15651219",

language = "English",

volume = "15",

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Price, A, Greenhall, G, Moody, W, Steeds, R, Mark, PB, Edwards, N, Hayer, M, Pickup, L, Radhakrishnan, A, Law, J, Banerjee, D, Campbell, T, Tomson, C, Cockcroft, J, Shrestha, B, Wilkinson, IB, Tomlinson, L, Ferro, C & Townend, J 2020, 'Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation', Clinical Journal of the American Society of Nephrology, vol. 15, no. 9, pp. 1330-1339. https://doi.org/10.2215/CJN.15651219

TY - JOUR

T1 - Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

AU - Price, Anna

AU - Greenhall, George

AU - Moody, William

AU - Steeds, Richard

AU - Mark, Patrick B

AU - Edwards, Nicky

AU - Hayer, Manvir

AU - Pickup, Luke

AU - Radhakrishnan, Ashwin

AU - Law, Jonathan

AU - Banerjee, Debasish

AU - Campbell, Tunde

AU - Tomson, Charles

AU - Cockcroft, John

AU - Shrestha, Badri

AU - Wilkinson, Ian B

AU - Tomlinson, Laurie

AU - Ferro, Charles

AU - Townend, Jon

PY - 2020/9/7

Y1 - 2020/9/7

N2 - BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months.RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m 2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49). CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).

AB - BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months.RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m 2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49). CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).

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U2 - 10.2215/CJN.15651219

DO - 10.2215/CJN.15651219

M3 - Article

C2 - 32843374

SN - 1555-9041

VL - 15

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EP - 1339

JO - Clinical Journal of the American Society of Nephrology

JF - Clinical Journal of the American Society of Nephrology

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Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

Abstract

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