Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Genomics England Research Consortium; Lucy Hare; Jamie Trotman; Patrick Tarpey; Elizabeth Hook; G. A.Amos Burke

doi:10.1002/pbc.30810

Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Genomics England Research Consortium
, Lucy Hare
, Jamie Trotman
, Patrick Tarpey
, Elizabeth Hook
, G. A.Amos Burke^*

^*Corresponding author for this work

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

86 Downloads (Pure)

Abstract

We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.

Original language	English
Journal	Pediatric Blood and Cancer
Early online date	16 Dec 2023
DOIs	https://doi.org/10.1002/pbc.30810
Publication status	E-pub ahead of print - 16 Dec 2023

Bibliographical note

Funding Information:
Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117).

Publisher Copyright:
© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

Keywords

HGBL
lymphoma
MLLT10
NOS

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.30810Licence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

HareL2023ChallengingFinal published version, 1.13 MBLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

Cite this

Genomics England Research Consortium, Hare, L., Trotman, J., Tarpey, P., Hook, E., & Burke, G. A. A. (2023). Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion. Pediatric Blood and Cancer. Advance online publication. https://doi.org/10.1002/pbc.30810

@article{ee099e8f87294a40b66dbbb4330d557b,

title = "Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion",

abstract = "We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.",

keywords = "HGBL, lymphoma, MLLT10, NOS",

author = "\{Genomics England Research Consortium\} and Lucy Hare and Jamie Trotman and Patrick Tarpey and Elizabeth Hook and Burke, \{G. A.Amos\}",

note = "Funding Information: Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117). Publisher Copyright: {\textcopyright} 2023 The Authors. Pediatric Blood \& Cancer published by Wiley Periodicals LLC.",

year = "2023",

month = dec,

day = "16",

doi = "10.1002/pbc.30810",

language = "English",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley",

}

TY - JOUR

T1 - Challenging our understanding of B-cell lymphomagenesis and risk

T2 - Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

AU - Genomics England Research Consortium

AU - Hare, Lucy

AU - Trotman, Jamie

AU - Tarpey, Patrick

AU - Hook, Elizabeth

AU - Burke, G. A.Amos

N1 - Funding Information: Lucy Hare is supported with funding from a Cancer Research UK Cambridge Centre clinical research fellowship (grant number: C9685/A25117). Publisher Copyright: © 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

PY - 2023/12/16

Y1 - 2023/12/16

N2 - We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.

AB - We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.

KW - HGBL

KW - lymphoma

KW - MLLT10

KW - NOS

UR - https://www.scopus.com/pages/publications/85179926351

U2 - 10.1002/pbc.30810

DO - 10.1002/pbc.30810

M3 - Article

C2 - 38102963

AN - SCOPUS:85179926351

SN - 1545-5009

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

ER -

Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this