CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

H Qureischie; Reinhard Heun; D Luetjohann; J Popp; F Jessen; C Ledschbor-Frahnert; H Thiele; W Maier; F Hentschel; P Kelemen; H Koelsch

doi:10.1016/j.brainres.2008.07.047

CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

H Qureischie, Reinhard Heun, D Luetjohann, J Popp, F Jessen, C Ledschbor-Frahnert, H Thiele, W Maier, F Hentschel, P Kelemen, H Koelsch

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Abstract

Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putative functional CETP polymorphisms (-1946 VNTR, C-629A and 1405V) on the risk of Alzheimer's disease (AD) and on cholesterol, lathosterol and 24S-hydroxycholesterol levels in CSF and plasma of AD patients and controls. None of the investigated CETP polymorphisms or haplotypes had any effect on the risk of AD. However, we found that a three marker CETP haplotype (L/C/V) influenced CSF levels of lathosterol and 24S-hydroxycholesterol as well as plasma levels of total cholesterol in controls but not in AD patients. Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk. (C) 2008 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Brain Research
Volume	1232
DOIs	https://doi.org/10.1016/j.brainres.2008.07.047
Publication status	Published - 1 Sept 2008

Keywords

APOE4
Alzheimer's disease
CETP
Cholesterol

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10.1016/j.brainres.2008.07.047

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title = "CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk",

abstract = "Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putative functional CETP polymorphisms (-1946 VNTR, C-629A and 1405V) on the risk of Alzheimer's disease (AD) and on cholesterol, lathosterol and 24S-hydroxycholesterol levels in CSF and plasma of AD patients and controls. None of the investigated CETP polymorphisms or haplotypes had any effect on the risk of AD. However, we found that a three marker CETP haplotype (L/C/V) influenced CSF levels of lathosterol and 24S-hydroxycholesterol as well as plasma levels of total cholesterol in controls but not in AD patients. Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk. (C) 2008 Elsevier B.V. All rights reserved.",

keywords = "APOE4, Alzheimer's disease, CETP, Cholesterol",

author = "H Qureischie and Reinhard Heun and D Luetjohann and J Popp and F Jessen and C Ledschbor-Frahnert and H Thiele and W Maier and F Hentschel and P Kelemen and H Koelsch",

year = "2008",

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doi = "10.1016/j.brainres.2008.07.047",

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TY - JOUR

T1 - CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

AU - Qureischie, H

AU - Heun, Reinhard

AU - Luetjohann, D

AU - Popp, J

AU - Jessen, F

AU - Ledschbor-Frahnert, C

AU - Thiele, H

AU - Maier, W

AU - Hentschel, F

AU - Kelemen, P

AU - Koelsch, H

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putative functional CETP polymorphisms (-1946 VNTR, C-629A and 1405V) on the risk of Alzheimer's disease (AD) and on cholesterol, lathosterol and 24S-hydroxycholesterol levels in CSF and plasma of AD patients and controls. None of the investigated CETP polymorphisms or haplotypes had any effect on the risk of AD. However, we found that a three marker CETP haplotype (L/C/V) influenced CSF levels of lathosterol and 24S-hydroxycholesterol as well as plasma levels of total cholesterol in controls but not in AD patients. Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk. (C) 2008 Elsevier B.V. All rights reserved.

AB - Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL). Variations in the CETP gene may cause CETP deficiency, which is characterized by decreased mass and activity of the protein as well as altered HDL and LDL levels. We investigated the effect of three putative functional CETP polymorphisms (-1946 VNTR, C-629A and 1405V) on the risk of Alzheimer's disease (AD) and on cholesterol, lathosterol and 24S-hydroxycholesterol levels in CSF and plasma of AD patients and controls. None of the investigated CETP polymorphisms or haplotypes had any effect on the risk of AD. However, we found that a three marker CETP haplotype (L/C/V) influenced CSF levels of lathosterol and 24S-hydroxycholesterol as well as plasma levels of total cholesterol in controls but not in AD patients. Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk. (C) 2008 Elsevier B.V. All rights reserved.

KW - APOE4

KW - Alzheimer's disease

KW - CETP

KW - Cholesterol

U2 - 10.1016/j.brainres.2008.07.047

DO - 10.1016/j.brainres.2008.07.047

M3 - Article

C2 - 18680734

VL - 1232

SP - 1

EP - 6

JO - Brain Research

JF - Brain Research

ER -

CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk

Abstract

Keywords

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