Cerebral blood flow and arterial transit time responses to exercise training in older adults

Jack Feron; Foyzul Rahman; Sindre H Fosstveit; Kelsey E Joyce; Ahmed Gilani; Hilde Lohne-Seiler; Sveinung Berntsen; Karen J Mullinger; Katrien Segaert; Samuel J E Lucas

doi:10.1016/j.neuroimage.2024.120919

Cerebral blood flow and arterial transit time responses to exercise training in older adults

Jack Feron, Foyzul Rahman, Sindre H Fosstveit, Kelsey E Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, Katrien Segaert, Samuel J E Lucas

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Abstract

Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBF_GM) reductions and lengthening arterial transit time (ATT_GM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBF_GM and ATT_GM remain unclear. This randomised controlled trial assessed responses of CBF_GM and ATT_GM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBF_GM or ATT_GM were associated with changes in cognitive functions. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBF_GM and ATT_GM. Results showed no between-group differences in CBF_GM or ATT_GM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆V̇O_2peak >2 mL/kg/min) experienced global CBF_GM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBF_GM or ATT_GM. Our findings indicate that exercise training in older adults may induce global CBF_GM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.

Original language	English
Article number	120919
Number of pages	12
Journal	NeuroImage
Volume	303
Early online date	5 Nov 2024
DOIs	https://doi.org/10.1016/j.neuroimage.2024.120919
Publication status	Published - 1 Dec 2024

Bibliographical note

Keywords

Ageing
Cerebral blood flow
Arterial transit time
Exercise training
Cognitive function

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title = "Cerebral blood flow and arterial transit time responses to exercise training in older adults",

abstract = "Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBFGM and ATTGM remain unclear. This randomised controlled trial assessed responses of CBFGM and ATTGM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBFGM or ATTGM were associated with changes in cognitive functions. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBFGM and ATTGM. Results showed no between-group differences in CBFGM or ATTGM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆{\.V}O2peak >2 mL/kg/min) experienced global CBFGM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBFGM or ATTGM. Our findings indicate that exercise training in older adults may induce global CBFGM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.",

keywords = "Ageing, Cerebral blood flow, Arterial transit time, Exercise training, Cognitive function",

author = "Jack Feron and Foyzul Rahman and Fosstveit, {Sindre H} and Joyce, {Kelsey E} and Ahmed Gilani and Hilde Lohne-Seiler and Sveinung Berntsen and Mullinger, {Karen J} and Katrien Segaert and Lucas, {Samuel J E}",

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doi = "10.1016/j.neuroimage.2024.120919",

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AU - Feron, Jack

AU - Rahman, Foyzul

AU - Fosstveit, Sindre H

AU - Joyce, Kelsey E

AU - Gilani, Ahmed

AU - Lohne-Seiler, Hilde

AU - Berntsen, Sveinung

AU - Mullinger, Karen J

AU - Segaert, Katrien

AU - Lucas, Samuel J E

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N2 - Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBFGM and ATTGM remain unclear. This randomised controlled trial assessed responses of CBFGM and ATTGM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBFGM or ATTGM were associated with changes in cognitive functions. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBFGM and ATTGM. Results showed no between-group differences in CBFGM or ATTGM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆V̇O2peak >2 mL/kg/min) experienced global CBFGM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBFGM or ATTGM. Our findings indicate that exercise training in older adults may induce global CBFGM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.

AB - Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBFGM and ATTGM remain unclear. This randomised controlled trial assessed responses of CBFGM and ATTGM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBFGM or ATTGM were associated with changes in cognitive functions. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBFGM and ATTGM. Results showed no between-group differences in CBFGM or ATTGM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆V̇O2peak >2 mL/kg/min) experienced global CBFGM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBFGM or ATTGM. Our findings indicate that exercise training in older adults may induce global CBFGM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.

KW - Ageing

KW - Cerebral blood flow

KW - Arterial transit time

KW - Exercise training

KW - Cognitive function

U2 - 10.1016/j.neuroimage.2024.120919

DO - 10.1016/j.neuroimage.2024.120919

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SN - 1053-8119

VL - 303

JO - NeuroImage

JF - NeuroImage

M1 - 120919

ER -

Cerebral blood flow and arterial transit time responses to exercise training in older adults

Abstract

Bibliographical note

Keywords

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