Centre selection for clinical trials and the generalisability of results: a mixed methods study

Adrian Gheorghe; Tracy E Roberts; Jonathan C Ives; Benjamin R Fletcher; Melanie Calvert

doi:10.1371/journal.pone.0056560

Centre selection for clinical trials and the generalisability of results: a mixed methods study

Adrian Gheorghe, Tracy E Roberts, Jonathan C Ives, Benjamin R Fletcher, Melanie Calvert

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The rationale for centre selection in randomised controlled trials (RCTs) is often unclear but may have important implications for the generalisability of trial results. The aims of this study were to evaluate the factors which currently influence centre selection in RCTs and consider how generalisability considerations inform current and optimal practice.

Original language	English
Pages (from-to)	e56560
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0056560
Publication status	Published - 2013

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abstract = "The rationale for centre selection in randomised controlled trials (RCTs) is often unclear but may have important implications for the generalisability of trial results. The aims of this study were to evaluate the factors which currently influence centre selection in RCTs and consider how generalisability considerations inform current and optimal practice.",

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Centre selection for clinical trials and the generalisability of results: a mixed methods study

Abstract

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