Central sympathetic overactivity: Maladies and mechanisms

James Fisher, CN Young, PJ Fadel

Research output: Contribution to journalArticle

103 Citations (Scopus)


There is growing evidence to suggest that many disease states are accompanied by chronic elevations in sympathetic nerve activity. The present review will specifically focus on central sympathetic overactivity and highlight three main areas of interest: 1) the pathological consequences of excessive sympathetic nerve activity; 2) the potential role of centrally derived nitric oxide in the genesis of neural dysregulation in disease; and 3) the promise of several novel therapeutic strategies targeting central sympathetic overactivity. The findings from both animal and human studies will be discussed and integrated in an attempt to provide a concise update on current work and ideas in these important areas.
Original languageEnglish
JournalAutonomic Neuroscience
Publication statusPublished - 5 Mar 2009


  • Sympathetic nerve activity
  • Nitric oxide


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