Cellular stress associated with aneuploidy

Jin Zhu, Molly R. Gordon, Rong Li*, Hung-Ji Tsai

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)
126 Downloads (Pure)

Abstract

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.

Original languageEnglish
Pages (from-to)420-431
Number of pages12
JournalDevelopmental Cell
Volume44
Issue number4
DOIs
Publication statusPublished - 26 Feb 2018

Keywords

  • aneuploidy
  • metabolic stress
  • mitotic stress
  • proteotoxic stress
  • replication stress

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry,Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology

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